Prospective Data Analysis of the Development of Hypernatremia in Intensive Care Unit

Insight in the Development and Recovery of Hypernatremia in Critically Ill Patients.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03752450

Acronym

HYPNIC

Enrollment

200

Registered

2018-11-26

Start date

2018-05-25

Completion date

2019-04-10

Last updated

2019-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypernatremia

Keywords

Water-electrolyte imbalance

Brief summary

Hypernatremia is frequently encountered in patients admitted to the Intensive Care Unit (ICU) and associated with increased mortality and length of stay. Previous studies focused on predictors in the development and recovery of hypernatremia by including amount and types of administered medication, fluid balance, laboratory results and changes in vital signs. However, data of larger populations or data on infusion rates, fluid and salt balance or renal replacement therapy is lacking. This study aims to provide better insight in the development and recovery of hypernatremia through the collection of detailed information on the input and output of fluids and salts in a larger group of patients than studied before.

Detailed description

Hypernatremia is frequently encountered in patients admitted to the Intensive Care Unit (ICU) and associated with increased mortality and length of stay. The main mechanism is an imbalance between sodium and total body water. Consequently, this poses multiple factors to play a role in the development of hypernatremia. multifactorial. Previous studies focused on predictors in the development of hypernatremia by including amount and types of administered medication, fluid balance, laboratory results and changes in vital signs. However, data of larger populations or data on infusion rates, fluid and salt balance or renal replacement therapy is lacking. Few studies investigated the recovery of hypernatremia, which showed that correction of hypernatremia can reduce the associated mortality risk. This study aims to provide better insight in the development and recovery of hypernatremia through the collection of detailed information on the input and output of fluids and salts in a larger group of patients than studied before.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adults \>17 years old * Admitted \>48 hours in ICU

Exclusion criteria

\- Expected discharge same day as day of inclusion

Design outcomes

Primary

Measure	Time frame	Description
Development of hypernatremia	During ICU admission	Serum sodium levels \>145mmol/L
Recovery of hypernatremia	During ICU admission	Serum sodium levels returning back to levels below 146mmol/L

Secondary

Measure	Time frame	Description
Mortality	During ICU admission as well as during hospital admission	Patient did or did not pass away.
Length of stay	Admission in ICU as well as in hospital	Number of days of admission

Countries

Netherlands

Outcome results