Extracorporeal Circulation; Complications
Conditions
Brief summary
In this study the investigators will study two dosages of heparin before extracorporeal circulation in open chest cardiac surgery.
Detailed description
In this study the investigators will study two dosages of heparin before extracorporeal circulation in open chest cardiac surgery. The first dosage will be 300 IU per kilogram of REAL weight, the second dosage will be 300 IU per kilogram of IDEAL weight.
Interventions
DIAGNOSTIC_TESTACT (Activated Clotting Time)
Measure of ACT in the two arms in order to determine if injection of heparin based on ideal weight is better or not than those one on real weight.
DRUGHeparin
300 IU of heparin
Sponsors
Astes
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Caregiver, Investigator)
Masking description
Randomisation by computer, different sheet for encoding data.
Intervention model description
One arm will receive 300 IU of heparin based on real weight, and the other arm will receive 300 IU of heparin based on ideal weight.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients admitted for cardiac open chest surgery
Exclusion criteria
* Patient's refusal * Antithrombin III factor \< 75% * Patient under treatment by heparin IV
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ACT performance | 1 minute | Measure of ACT to be \> 400 seconds to allow extracorporeal circulation, but also \< 700 seconds to avoid excessive bleeding. |
Countries
Belgium
Outcome results
None listed