Genetic an Functional Studies of Patient With Inflammatory Bowel Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03751722

Acronym

MINOTOR

Enrollment

630

Registered

2018-11-23

Start date

2007-02-28

Completion date

2017-04-10

Last updated

2018-11-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammatory Bowel Diseases

Keywords

Crohn disease, Ulcerative colitis, genetic makers, cytokines

Brief summary

The objective of this study is to study the response of macrophages, isolated from patients with ulcerative colitis (Crohn's disease) or Crohn's disease (CD), to 6 candidate enterogenous and their derivatives, depending on the genotype for associated polymorphisms. to the development of IBD

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

6 Years to No maximum

Healthy volunteers

Inclusion criteria

* patient with definite crohn's disease or ulcerative colitis

Exclusion criteria

* patient receiving anti-TNF therapy during 14 days before inclusion.

Design outcomes

Primary

Measure	Time frame	Description
Isolated macrophage response measured by PCR	Baseline: one session	identification of macrophage activation markers specific analysis of gene expression (by PCR in real time) and / or the production (ELISA) of proinflammatory molecules (IL-6, TNF-1 and IL-8), anti-inflammatory (IL-10) and immunomodulatory (IL4,PPAR -2, MOR)

Countries

France

Outcome results