Indirect Measurement of Respiratory Quotient in Unipulmonary Ventilation.

Validation of the Respiratory Quotient Measurement Measured Indirectly in Unipulmonary Ventilation (UNIQ Study)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03751605

Enrollment

Registered

2018-11-23

Start date

2018-11-01

Completion date

2023-02-01

Last updated

2023-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Quotient Measurement

Keywords

unipulmonary ventilation, complications, respiratory quotient.

Brief summary

The measurement of VO2 and VCO2 makes it possible to calculate the respiratory quotient (RQ) (VCO2 / VO2) which is a reflection of human energy metabolism and therefore of anaerobiosis. A study has been conducted in our department to demonstrate the ability of the indirectly measured respiratory quotient (RQ) from the inspired and exhaled breath analysis of the anesthetic respirator to predict the onset of anaerobic metabolism and postoperative complications in the operating room. Unipulmonary ventilation is the rule in thoracic surgery: it improves surgical exposure and protects the operated lung. However, no study has examined the impact of these mechanisms on the indirect measurement of RQ in unipulmonary ventilation. The main objective of our work is to validate indirect RQ measurement during unipulmonary ventilation. The secondary objective was to assess the predictability of postoperative complications of indirect QR.

Interventions

PROCEDUREunipulmonary ventilation

observational study based on the computation of respiratory quotient in patient cohort treated by unipulmonary ventilation in routine thoracic surgery

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* Age\>18 years old * Adults admitted to the operating room for thoracic surgery requiring unipulmonary ventilation

Exclusion criteria

* Cardiac surgery * Laparoscopy * Preoperative oxygen therapy

Design outcomes

Primary

Measure	Time frame
Indirect respiratory quotient	during surgery

Secondary

Measure	Time frame	Description
occurrence of at least one post-operative complication	through study completion, an average of 6 months	the aim is to predict the occurrence of at least one complication with the use of indirect respiratory quotient

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026