Exercise
Conditions
Brief summary
The aim of this study is to investigate the effects of regular sucrose feeds compared to a single large bolus given late in exercise, on muscle glycogen utilisation, exercise capacity and other markers of metabolism during running
Interventions
OTHERRegular carbohydrate feeding
60 ml of water with 5 g sucrose given every 5 minutes 14 times up until 70 minutes followed by 5 g sucrose after 75 minutes in a 250 ml solution
OTHERSingle carbohydrate bolus
60 ml of water given every 5 minutes 14 times up until 70 minutes followed by 75 g sucrose after 75 minutes in a 250 ml solution
Sponsors
University of Bath
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Self-identify as a trained runner * Regularly participate in running activity (\>2 times a week) * Participated in running based training for a minimum of 2 years * Be willing to undertake exercise sessions until volitional exhaustion * Be willing to have the necessary samples taken during the testing protocols * Not a habitual smoker * Have the capacity and willingness to provide informed consent (oral and written) * Successful completion of the physical activity readiness questionnaire (PAR-Q)
Exclusion criteria
* Female * \<18 or \>50 years old * Not regularly participating in running activity (\<3 times a week) * Experience contraindications to the administration of the proposed anaesthetic (Lidocaine Hydrochloride) * Habitual/previously habitual smoker
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle glycogen concentrations | Estimated to be between 90 and 145 minutes | Muscle glycogen concentration at rest, after 75 minutes of treadmill running and at volitional exhaustion. Measured using the bergstrom needle technique for obtaining muscle biopsy samples |
| Exercise capacity | Estimated to be between 90 and 145 minutes | Time to exhaustion at the pre-determined speed to elicit exhaustion after \ 90 minutes when ingesting water only |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Carbohydrate oxidation | Estimated to be between 90 and 145 minutes | Total carbohydrate oxidation during treadmill running. Measured using indirect calorimetry and reported in grams. |
| Fat oxidation | Estimated to be between 90 and 145 minutes | Total fat oxidation during treadmill running. Measured using indirect calorimetry and reported in grams. |
| Plasma glucose concentrations | Estimated to be between 90 and 145 minutes | Plasma lactate concentrations during of treadmill running. Measured using colourimetric assay and reported in mmol/L |
| Ratings of perceived exertion | Estimated to be between 90 and 145 minutes | Subjective ratings of perceived exertion, during treadmill running. Measured using a borg scale of 6 to 20, where 6 = no exertion at all, and 20 = maximal exertion. |
| Heart rate | Estimated to be between 90 and 145 minutes | Heart rate during treadmill running measured by telemetry and reported in beats per minute |
| Rate of oxygen consumption | Estimated to be between 90 and 145 minutes | Rate of oxygen consumption during treadmill running. Measured using indirect calorimetry and reported in litres per minute |
| Rate of carbon dioxide production | Estimated to be between 90 and 145 minutes | Rate of carbon dioxide production during treadmill running. Measured using indirect calorimetry and reported in litres per minute. |
| Plasma lactate concentrations | Estimated to be between 90 and 145 minutes | Plasma lactate concentrations during treadmill running. Measured using colourimetric assay and reported in mmol/L. |
| Ratings of stomach discomfort | Estimated to be between 90 and 145 minutes | Subjective ratings of stomach discomfort during treadmill running. Measured using a modified borg scale of 6 to 20, where 6 = no discomfort and 20 = maximal discomfort |
Countries
United Kingdom
Outcome results
None listed