Cardiomyopathies, Chronic Kidney Diseases, Coronary Artery Disease, Heart Failure, Inflammatory Disease
Conditions
Keywords
T1 mapping, native T1, native T2, accuracy, prognosis
Brief summary
Mapping of magnetic relaxation within the myocardial tissue using T1 (and T2) mapping using cardiovascular magnetic resonance (CMR) are novel measures of quantifiable (scalable) myocardial tissue characterisation. Evidence suggests that myocardial mapping could be useful in detection of diffuse myocardial disease, complementing late gadolinium enhancement (LGE) as the tool for regional myocardial disease. A handful of studies, three single centre study of a single T1 index with outcomes and one multicentre study for all indices reported strong associations with all cause mortality and heart failure. These studies were based on a single-vendor platform and were using a single sequence. The main unknowns pertaining the successful translation of this technique and the transferability of the methodology beyond a single centre and lack of outcome evidence from broad and large populations. In this study, we will assess the diagnostic accuracy of T1 (and T2) mapping measurements in health and disease, and the prognostic relevance of T1 mapping measurements by associations with outcome. This study is builds upon/integrates the evidence of the NCT02407197 study, which remains active for follow-up, but is currently no longer recruiting.
Interventions
None listed
Sponsors
Kerckhoff Klinik
Johann Wolfgang Goethe University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
1. Adults (\>18 years of age) 2. Able to provide informed consent 3. Clinically indicated cardiac magnetic resonance imaging study
Exclusion criteria
contraindications for clinical cardiac magnetic resonance imaging due to MR unsafe devices or objects
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Survival | 1 year | number of deaths |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rate of Heart Failure events | 1 year | Number of participants with events including death and Hospitalisation due to Heart Failure |
| Rate of Arrhythmia | 1 year | Number of participants with events of documented Sudden Cardiac Death, appropriate ICD discharge, sustained VT |
| Rate of death due to to cardiovascular causes | 1 year | Number of participants with death due to myocardial infarction, heart failure, arrhythmia |
Countries
Germany
Outcome results
None listed