Inflammation and Cellular Immunity in Vaginal Tissue in Patients With Pelvic Organ Prolapse

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03748693

Enrollment

Registered

2018-11-21

Start date

2018-12-31

Completion date

2019-09-30

Last updated

2018-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pelvic Organ Prolapse

Brief summary

The aim of this study is to investigate the inflammatory and maturation processes of immature myeloid cells (IMC) in the vaginal tissue in women with advanced pelvic organ prolapse (POP) (stage III-IV) and in normal non-POP controls. We hypothesize that the processes contributing to POP may be related to immune response and changes in myeloid cell populations and the cytokine environment.

Interventions

PROCEDUREHysterectomy

Surgery performed on women with a variety of gynecological indications

PROCEDUREColporrhaphy

Surgery performed on women with POP

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 80 Years

Inclusion criteria

* Women with POP undergoing colporrhaphy * Women undergoing hysterectomy

Exclusion criteria

* Autoimmune and connective tissue disorders * Cancer in genital tract

Design outcomes

Primary

Measure	Time frame	Description
Cytokine environment in POP	Two weeks	Tissue biopsy will analyzed for cytokine environment and compared to control group
Immune response in POP	Two weeks	Tissue biopsy will analyzed for IMC and compared to control group

Contacts

Primary ContactMariana Ordonez, MD

malo_mariana@hotmail.com972-52-3243474

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026