Patients With Fatty Liver Disease
Conditions
Brief summary
This study investigates the relation between the gastrointestinal tract bacteria and the progression of fatty liver disease .
Detailed description
In the gastrointestinal (GI) tract live wide spectrum of bacteria, in this study we are trying to find if there is a relation between the GI tract bacteria and the development of non alcoholic fatty liver disease, the results of the this study may help us identify the stage of liver disease in noninvasive means and enables us to adopt methods to reduce morbodity.
Interventions
OTHERfibroscan and stool sample
patients undergo ultrasaound (fibroscan) in order to stage the liver disease.
Sponsors
HaEmek Medical Center, Israel
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Inclusion criteria
* patients with non alcoholic fatty liver disese. * patients who give approval to participate in the study
Exclusion criteria
* liver failure * acute or chronic kidney failure * heart failure ( NYHA 3-4) * active cancer * fatty liver due to non alcoholic etiology. * patients who consume drugs from the estrogen/methotrexate family, or chloroquine. * history of hypothyrodism or cushing. * patients who used TPA in the last 6 months . * pathients with chronic liver disease like A1AT, hemochromatosis, wilson, toxic damage and autoimmunity . * special population like - children, pregnant women and patients who lack the ability to make judgment. * infectious liver disease - viral hepatitis or HIV. * inflammatory bowel disease. * patients who underwent surgery of the gastrointestinal trant.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Transient Elastography Test | up to 2 hours | Ultrasound Elastography is a non-invasive test which uses the technology of Shear Wave Elastography (SWE) obtained from the right liver lobe for staging liver fibrosis according to Metavir Fibrosis Score . Metavir Fibrosis Score is a system used to assess the extent of inflammation and fibrosis by histopathological evaluation in a liver biopsy. Liver fibrosis assessed by Shear Wave Elastography is well correlated to biopsy using Metavir Score. The outcome of the test will be correlated to Metavir Score system according to the chart below: SWE (kiloPascal) , METAVIR score, Fibrosis Level. Below 5 , F0 , No fibrosis. 5.0-7.1 , F1 , Mild Fibrosis. 7.1-8.7 , F2 , Significant Fibrosis. 8.7-10.4 , F3 , Sever Fibrosis . 10.4-19 , F4 , Cirrhosis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gastrointestinal Microbiome test | up to 1 month | The test will be made by a new meta-genomic sequencing technology (Next Generation Sequencing) which gives us unbiased information about all the gastrointestinal bacterial characteristics. |
Countries
Israel
Outcome results
None listed