Premature Infant, Respiratory Disease
Conditions
Brief summary
SpO2 instability is in the nature of premature infants. Hypoxic episodes occur spontaneously in many of these infants, especially after the first week of life. Different interventions have been shown to influence the incidence of hypoxemic episodes in premature infants. Premature infants are fed via an NG/OG tube. Feeding length might influence the oxygenation instability among premature infants therefore the aim of this study is to evaluate the changes in oxygenation among preterm infants receiving respiratory support when are fed over 30 min vs over 2 hours, as documented by SpO2 histograms.
Interventions
PROCEDUREContinuous gavage feeding
Each subject will serve as his or her own control. In this arm infants will receive their feed over 2 hours and the next feed will be given over 30 min and then over 2 hours again.
PROCEDUREBolus feeding
Each subject will serve as his or her own control. In this arm infants will receive their feed over 30 min and the next feed will be given over 2 hours and then over 30 minutes again.
Sponsors
Rambam Health Care Campus
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
Premature Infants (GA\<37weeks) on non-invasive respiratory support (CPAP, NIPPV, HFNC) Feeding\>100 ml/kg/day
Exclusion criteria
Congenital anomalies e.g. gastroschesis, congenital diaphragmatic hernia, cyanotic heart disease. Instability because of: Acute lung pathology for example x-ray confirmed pneumonia, air leak Active culture proven sepsis Need for inotropic support for low blood pressure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oxygenation instability | 9 hours (3 feeds) | SPO2 histogram documents the oxygenation stability. we will record the histogram at the end of each period of time and compare it |
Countries
Israel
Outcome results
None listed