Healthy
Conditions
Brief summary
The objective of this study is to establish reference values in the general population from a Beckman Coulter DxI chemiluminescence assay. Indeed, the lack of harmonization of the methods of the dosage remains a major difficulty to optimize the management of patients with thyroid disease. This supplier has recently optimized its dosing kit according to the 3rd international standard of the WHO (IRB 81/565) for the TSH (Thyroid Stimulating Hormon). It is necessary to carry out a study of the distribution of the values of this TSH within our metropolitan population. The current data proposed by the supplier come from a study of a North American population. investigators propose to define usual values for thyroid status markers (TSH, FT4 \[free thyroxine\], FT3 \[free triiodothyroxine\]) from healthy EFS (French Blood Establishment) donors who meet the standard exclusion criteria for this type of study.
Interventions
OTHERDosages of Thyroid parameters
Dosages of the following parameters: TSH, FT4 FT3, TGAb (Tyroglobulin antibody) , TPO Ab (ThyroPeroxydase Antibody)
Sponsors
University Hospital, Caen
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Donors (18-70 years old) volunteers at EFS
Exclusion criteria
* pregnancy, * known antecedents of thyroid diseases (goiter, nodule, hypo or hyperthyroidism), * current antithyroid treatment (neomercazole \[Thyrozol(r)\], levothyroxyn LT4 \[levothyrox(r)\], ...), * cardiac treatment with amiodarone (cordarone(r)), * injection of iodinated contrast medium less than 1 month old
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Determination of the usual values of TSH | baseline | Determination of the usual values of TSH after assays on DxI automaton of the Beckman Company according to the standardization 3rd international standard (IRB 81/565) |
| Determination of the usual values of FT4 | baseline | Determination of the usual values of FT4 after assays on DxI automaton of the Beckman Company according to the standardization 3rd international standard (IRB 81/565) |
| Determination of the usual values of FT3 | baseline | Determination of the usual values of FT3 after assays on DxI automaton of the Beckman Company according to the standardization 3rd international standard (IRB 81/565) |
Outcome results
None listed