Diabetes Mellitus, Type 1
Conditions
Keywords
Continuous Subcutaneous Insulin Infusion, diet, postprandial glucose, postprandial hypoglycemia, postprandial hyperglycemia
Brief summary
Glycemia following pizza consumption is typically managed with a dual wave insulin bolus. This study evaluated the effect of a simple bolus on glycemia following consumption of traditionally prepared pizzas with long (22 hours) or short (8 hours) dough fermentation periods.
Detailed description
All participants received pizza prepared in one of two ways, as described below, on two separate days. On the first day, they were given a pizza prepared with dough fermented for 8 hours (pizza A), and on the second study day they received a pizza prepared with dough fermented for 24 hours (pizza B). Participants and their parents were blinded to the type of pizza served on each day. Both meals were served at 7.00 pm at the pizzeria where the pizza had been prepared, and consumed within 30 minutes. Children and adolescents aged between 4 and 18 years with type 1 diabetes were eligible for inclusion in the study if they had received SIP therapy (MiniMed™ 640G, Medtronic, Tolochenaz, Switzerland) for at least 3 months One pizza of each type was prepared for chemical analysis
Interventions
OTHERthe patients ate a pizza that fermented for 8 hours
Patients eat pizza prepared with controlled ingredients but fermented 8 hours
OTHERthe patients ate a pizza that fermented for 24 hours
Patients eat pizza prepared with controlled ingredients but fermented 24 hours
Sponsors
Federico II University
University of Campania Luigi Vanvitelli
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
4 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* type 1 diabetes if they had received sensor integrated pump (SIP) therapy for at least 3 months
Exclusion criteria
* Patients with HbA1c \>8.5% (69 mmol/mol), celiac disease, other food allergies or concurrent illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Continuous glucose sensor data | 11 hours | mmol/L |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Content of carbohydrates | 1 hour | µg/g |
Other
| Measure | Time frame | Description |
|---|---|---|
| Content of amino acids | 1 hour | µg/g |
Countries
Italy
Outcome results
None listed