Postoperative Complications Following Total Knee Arthroplasty

Comparison of Effects of Combined Spinoepidural and General Anesthesia Effects on Incidence of Postoperative Complications Following Total Knee Arthroplasty

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03746444

Enrollment

130

Registered

2018-11-19

Start date

2018-11-20

Completion date

2018-12-25

Last updated

2018-11-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arthroplasty, Replacement, Knee

Keywords

total knee arthroplasty, general anesthesia, neuraxial anesthesia, complications

Brief summary

The aim of this study is to investigate the effect of combined spinoepidural and general anesthesia on the incidence of postoperative complications following total knee arthroplasty

Detailed description

Total knee arthroplasty is known to cause complications (pulmonary thromboembolism, acute kidney injury, arryhthmias and infection). The investigators aimed to study the effects of two different anesthesia techniques, i.e. combined spinoepidural anesthesia and general anesthesia on the incidence of postoperative complications such as arrhythmia, pulmonary thrombeoembolism, infection, acute kidney injury and mortality.

Interventions

OTHERGeneral Anesthesia

The patients in general anesthesia group will undergo general anesthesia

OTHERRegional Anesthesia

The patients in Group R will be given combined spinoepidural anesthesia

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Patients scheduled to undergo elective unilateral total knee arthroplasty

Exclusion criteria

* Patient refusal * Scheduled for bilateral or unilateral unicondylar knee arthroplasty * Known history of allergy to drugs used in the study * Severe systemic disease * Morbid obesity (BMI\>30) * History of renal dysfunction

Design outcomes

Primary

Measure	Time frame	Description
Acute Kidney Injury	Postoperative first day	Number of participants with new onset acute kidney injury
Pulmonary Thromboembolism	Postoperative first day	Number of participants with new onset pulmonary thromboembolism
Infection	Postoperative first day	Number of participants with new onset infection
Arryhthmia	Postoperative first day	Number of participants with new onset arryhthmia requiring treatment
Death	Postoperative first day	Number of participants with mortality

Countries

Turkey (Türkiye)

Contacts

Primary ContactPerihan Ekmekçi, MD

erdogduperi@gmail.com+903122044000

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026