Transpulmonary Pressure Under Stressing Conditions

Transpulmonary Pressure Under Conditions of Increased Intra-abdominal Pressure From Pneumoperitoneum and Steep Trendelenburg

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03746236

Enrollment

Registered

2018-11-19

Start date

2018-11-14

Completion date

2019-12-30

Last updated

2019-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator-Induced Lung Injury

Brief summary

Study aims to prospectively evaluate if the pressures normally applied during mechanical ventilation in laparoscopic surgery induce stress on the pulmonary wall. To do this is used measure the variation of esophageal pressure, as indirect index of the pleural pressure and therefore of the transpulmonary pressure, in response to changes in airway pressures in a group of patients undergoing robotic assisted radical prostatectomy or videolaparoscopy.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* ASA (american society of anesthesiologists) score ≤ III * Patients underwent laparoscopic prostatectomy

Exclusion criteria

* BMI (body mass index) ≥ 30 * Impossibility to insert nasogastric tube * Anatomic rib cage alterations

Design outcomes

Primary

Measure	Time frame	Description
Incidence of postoperative acute complications	24 hours	Evaluation of pulmonary alterations using pre and postoperative ultrasonographic visualization
Dosage of inflammatory mediators	24 hours	Dosage of metalloproteinase and interleukin 8 in bronchoaspiration

Countries

Italy

Contacts

Primary ContactEster Forastiere, chief

ester.forastiere@ifo.gov.it

Outcome results