Pain, Quality of Life
Conditions
Keywords
Pericoronitis, Analgesics, Non steroid anti-inflammatory drugs, Benzydamine, Quality of life
Brief summary
Pericoronitis is a painful inflammatory condition which is well known for its negative impact on quality of life of those affected. The aim of this study was to test two hypotheses: (1) that topical application of Benzydamine is as effective as oral Diclofenac or Flurbiprofen in improving pain and quality of life of patients with pericoronitis and (2) that there would be no difference between the effects of the two oral NSAIDs on pain and quality of life of patients with pericoronitis
Interventions
DRUGDiclofenac
All patients were instructed to take one capsule orally every 8 h and apply the spray (4 puffs to the pericoronitis area) every 4 h for 7 days, commencing immediately after the clinical examination.
DRUGFlurbiprofen
All patients were instructed to take one capsule orally every 8 h and apply the spray (4 puffs to the pericoronitis area) every 4 h for 7 days, commencing immediately after the clinical examination.
DRUGBenzydamine
All patients were instructed to take one capsule orally every 8 h and apply the spray (4 puffs to the pericoronitis area) every 4 h for 7 days, commencing immediately after the clinical examination.
Sponsors
Near East University, Turkey
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Young adults aged 18 years or over * Diagnosed with mild pericoronitis * Having semi-impacted mandibular third molar * Symptoms of pain and localized swelling
Exclusion criteria
* Smoking * History of allergy to diclofenac, flurbiprofen, benzydamine or other NSAIDs * Use of systemic antibiotics or analgesics within 3 days before admission * The patients who had symptoms of severe pericoronitis such as fever higher than 101°F, dysphagia, trismus or facial swelling.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oral Health-Related Quality of Life Scores Evaluated | Baseline | For the pre- treatment period, the Oral Health-Related Quality of Life scores change was evaluated in the 1st day after the clinical examination and before the treatment with the help of the 5-point Likert-type scale where each item was scored from 1 (no trouble) to 5 (lots of trouble). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain Scores Evaluated | Baseline | For the pre-treatment period, the pain scores change was evaluated in the 1st day after the clinical examination and before the treatment with the help of the visual analog scale (VAS) ranging from 0 (no pain) to 10 (most severe pain). |
Other
| Measure | Time frame | Description |
|---|---|---|
| Oral Health Impact Profile (OHIP-14) Scores Evaluated | Baseline and one week after drug prescribed | Before and after the treatment period, the Oral Health Impact Profile scores change was evaluated in the 1st day after the clinical examination and before the treatment (baseline), and after 7 days with the help of the 5-point scale where each item was scored from never = 0, hardly ever = 1, occasionally = 2, fairly often = 3, very often = 4 |
Countries
Turkey (Türkiye)
Outcome results
None listed