Electronic Cigarettes
Conditions
Brief summary
This project will assess the ways in which e-cigarette product diversity impacts the user experience to inform potential regulations by identifying product characteristics that may: (1) put young adults at risk for tobacco product use; and (2) facilitate adult smokers switching to e-cigarettes. There are three primary objectives to the study: (1) Determine which dimensions of e-cigarette product diversity differentially affect product appeal across young adult e-cigarette users and middle-age/older adult smokers with an interest in, but no significant experience with, e-cigarettes; (2) Determine which dimensions of e-cigarette product diversity differentially affect abuse liability in young adult e-cigarette users and the ability to resist smoking in adult smokers with an interest in, but no significant experience with, e-cigarettes; (3) Determine the affect of product characteristics on e-cigarette nicotine delivery profile. For Aim 1, young adult vapers (N=200) and adult smokers (N=200) will attend one laboratory session in which they will self-administer e-cigarette products varied according to within-subject e-cigarette factors (e.g., flavor, pg/vg ratio). For Aim 2, young adults vapers (N=360) and adult smokers (N=360) will administer an e-cigarette product and complete behavioral economic tasks that test the participant's choice of earning money to delay initiation and continued use of: (1) The sampled e-cigarette product (abuse liability; young adult vapers); or (2) Their own brand cigarettes (ability to resist smoking; adult current smokers). A pilot study will establish device and e-liquid parameters (e.g., nicotine concentration) to be used for all aims.
Interventions
OTHERe-Cigarette
Participants will self-administer an experimenter-provided e-cigarette.
Sponsors
University of Southern California
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Vapers 1. E-cigarette use \>3 day/week for \>2 months 2. Report regularly using e-cigarette products with nicotine 3. Positive cotinine test via NicAlert test strip Smokers 1. Daily cigarette smoking for ≥ 2 years 2. Currently smoke \> 4 cig/day 3. Interest in trying an e-cigarette or current use of e-cigarettes
Exclusion criteria
Vapers 1. Pregnancy/breastfeeding 2. Desire to immediately reduce e-cigarette use Smokers 1. Breath CO \< 9ppm at intake 2. Pregnancy / breastfeeding 3. Current daily use of other combustible tobacco products (e.g., cigars)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Subjective Appeal | 1 hour | Self-report measures of product appeal will be completed following the e-cigarette administration. |
| Positive Affect Negative Affect Schedule | 4 hours | The 10-item Positive Affect Negative Affect Schedule (PANAS-SF) will be used to measure positive and negative affect. |
| Questionnaire of Vaping Urges | 4 hours | 10-item Brief Questionnaire of Vaping Urges will assess desire, intention, urge and need to vape e-cigarettes. |
Countries
United States
Outcome results
None listed