Development, Child
Conditions
Keywords
Vitamin D Receptor gene, physical development, intelligent development
Brief summary
This study was used to determine the relationship between vitamin D receptor gene polymorphism and children's physical and intellectual development, further adjust the doses of vitamin D supplementation after birth, and provide individualized vitamin D and calcium supplements.
Detailed description
High risk children aged 0-3 years old who visited the pediatrics clinic and ward of the first affiliated hospital of Xi'an Jiaotong university and other cooperative hospitals from 2018 to 2020 were randomly selected. Personal information of the children and parents who were enrollment was collected by questionnaire survey and a follow-up file was established. 500 to 1,000 people are planned to participate in the study, were randomly divided into research group and the control group. Then collect the sample(saliva) of children to examine Vitamin D Receptor(VDR) genotype, according to results, divide the research group into high, medium and low risk, given individual vitamin D and calcium supplement. Monitor the children's weight, body length, head circumference, the Neonatal Behavioral Assessment Scale(NBAS), bailey rating scale respectively, up to 3 years old. All sample analyses were performed by the Gene Medical Laboratory. Laboratory personnel were blinded to mother and infant outcomes.
Interventions
DRUGVitamin D
Vitamin D is essential for healthy bones, and to control the amount of calcium in our blood.It is important at every stage of life, but especially for rapidly growing infants and teenagers and for pregnant and breastfeeding women.
Sponsors
Xian Children's Hospital
The First Affiliated Hospital of Zhengzhou University
First Affiliated Hospital Xi'an Jiaotong University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
1 Days to 3 Years
Healthy volunteers
Yes
Inclusion criteria
* infant age from 0 to 3 years old * enjoy good health, there is no history of specific diseases
Exclusion criteria
* this time or always exists serious lung infection, or with nervous system disease, kidney disease, malignant tumor, etc * has bone metabolic diseases or other genetic metabolic disease * taking affect bone metabolism of drugs for a long time
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| body height | From date of randomization until the date of three year-old | We will use the baby scale to measure infant body height |
| body weight | From date of randomization until the date of three year-old | We will use the baby scale to measure infant body weight |
| head circumference | From date of randomization until the date of three year-old | We will use the tape to measure infant head circumference |
Countries
China
Contacts
Primary ContactHui Li, PHD,MD
Backup ContactZhongliang Zhu, PHD
Outcome results
None listed