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Viscosity of Fibre Predicts Cholesterol-lowering in Healthy Individuals

Viscosity Rather Than Quality of Dietary Fibre Predicts Cholesterol-lowering Effect in Healthy Individuals

Status
Completed
Phases
Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03741621
Enrollment
23
Registered
2018-11-15
Start date
1992-01-31
Completion date
2010-07-31
Last updated
2018-11-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lipidemia, Healthy

Keywords

dietary fibre, Viscosity, lipids, Healthy

Brief summary

To investigate the role of fibre viscosity (low, medium, high) in lowering cholesterol in healthy individuals

Interventions

DIETARY_SUPPLEMENTViscous Fibre Blend

High viscosity viscous fiber blend sprinkled on wheat and maize bran cereals(Bran Buds®; Kellogg Company)

DIETARY_SUPPLEMENTPsyllium

Bran Buds cereal (white bran and maize bran) with psyllium (Bran Buds® with PSY; Kellogg Company)

DIETARY_SUPPLEMENTWheat Bran

All Bran cereal (All Bran®; Kellogg Company)

Sponsors

Kellogg Company
CollaboratorINDUSTRY
University of Toronto
CollaboratorOTHER
Unity Health Toronto
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes

Inclusion criteria

-healthy individuals

Exclusion criteria

* regular alcohol consumption * regular smoking

Design outcomes

Primary

MeasureTime frame
change in LDL cholesterolchange from baseline after 21 days, relative to control

Secondary

MeasureTime frame
change in total cholesterolchange from baseline after 21 days, relative to control
change in triglycerideschange from baseline after 21 days, relative to control
change in HDL cholesterolchange from baseline after 21 days, relative to control
change in apolipoprotein Bchange from baseline after 21 days, relative to control
change in apolipoprotein A-1change from baseline after 21 days, relative to control

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026