Anesthetics, Intravenous, Anxiety, Depression, Propofol
Conditions
Keywords
Female, Prospective Studies, Anesthetics, Intravenous, Propofol, Anxiety/*psychology, Depression/*psychology
Brief summary
120 consecutive female patients, 18-65 years old, American Society of Anesthesiologists (ASA) physical status I to II, scheduled for hysteroscopic surgery under propofol-based intravenous anesthesia will be recruited in this cohort study. The day before surgery, participants will be assessed the state of preoperative anxiety and depression. On the day of surgery, propofol will be administered by target controlled infusion (TCI) pump. During induction of anesthesia, the level of sedation will be evaluated. The induction dose of propofol, target effect-site concentration(Cet), plasma concentration(Cp) and effect-site concentration (Ce) of propofol will be recorded.
Detailed description
120 consecutive female patients, 18-65 years old, American Society of Anesthesiologists ( ASA) physical status I to II, scheduled for hysteroscopic surgery under propofol-based intravenous anesthesia will be recruited in this prospective cohort study. The day before surgery, participants were asked to complete the modified HADS questionnaire in an isolated calm room, and the score was used to assess the patients' anxiety and depression level in the past 6 months. On the day of surgery, propofol (Fresenius Kabi Austria GmbH, Graz, Austria)was administrated by using an intravenous target controlled infusion (TCI) pump (Alaris PK, Basingstoke, UK) with Schnider kinetic model. The initial effect-site concentration (Ce) was set as 1.0 μg/ml. After the TCI system displayed that Cp and Ce were at equilibrium, the target concentration of propofol was increased by an increment of 0.5 μg/ml until the patients achieved the three desired levels of sedation.The Ce and dose of propofol and the consuming time were recorded.
Interventions
OTHERanxiety and depression
Female patients who have a previous history of surgery or infertility, or a history of miscarriage or abortion are often susceptible to preoperative anxiety or depression. We will observe the effect of anxiety and depression on the dosage of propofol during induction.
Sponsors
Xuyu Zhang
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* female * American Society of Anesthesiologists（ASA） physical status I or II * Body Mass Index(BMI) 18-25kg/m2 * scheduled for hysteroscopic surgery under propofol-based intravenous anesthesia.
Exclusion criteria
* suffering from psychiatric diseases. * chronic use of anxiolytics, antidepressants, and sedative-hypnotics. * any sedative premedication. * a history of alcohol abuse. * allergy to propofol. * declining to participate and cooperate.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect-site concentration (Ce) of propofol | Time of induction is less than 10 minutes. | Effect-site concentration (Ce) of propofol on the TCI-system at the sedative level of OAA/S score of 3, OAA/S score of 1, and OAA/S core of 1 and NI\<64 reached will be recorded. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The induction dose of propofol | Time of induction is less than 10 minutes. | The dose of propofol required at the sedative level of OAA/S score of 3, OAA/S score of 1, and OAA/S core of 1 and NI\<64 reached will be recorded. |
Countries
China
Outcome results
None listed