Prostate Cancer
Conditions
Keywords
lung ultrasonography, mechanical ventilation, pressure controlled ventilation, volume controlled ventilation
Brief summary
This study will be performed in robotic assisted laparoscopic radical prostatectomy patients in Cerrahpasa Medical Faculty Monoblock Operating Room. Since robot-assisted laparoscopic radical prostatectomy is a surgical procedure which requires long-term mechanical ventilation, excessive trendelenburg position (30-45 °) and pneumoperitoneum; these interventions may lead to respiratory complications such as ventilation difficulty and aeration loss in patients. Nowadays, lung ultrasonography has been used in anesthesia practice and intensive care units in order to determine lung aeration loss. In this study, the investigators aimed to compare the possible aeration loss in lung parenchyma during pressure controlled ventilation and volume controlled ventilation which are frequently used in anesthesia practice in patients undergoing robotic radical prostatectomy.
Interventions
Patients will be ventilated with a pressure level which supplies a tidal volume corresponding 8ml/kg, 12 breaths per minute, 1/2 inspiration/expiration ratio and %40 Fraction of Inspired Oxygen . These ventilator settings can be changed in order to adjust end tidal carbon dioxide and oxygen saturation levels.
Patients will be ventilated with a tidal volume which corresponds 8ml/kg, 12 breaths per minute, 1/2 inspirastion/expiration ratio and %40 Fraction of Inspired Oxygen . These ventilator settings can be changed in order to adjust end tidal carbon dioxide and oxygen saturation levels.
Sponsors
Istanbul University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
18-75 age * Patient who will be undergo robot assisted laparoscopic prostatectomy surgery * Patient with ASA (American Society of Anesthesiologists) Score 1-3
Exclusion criteria
* Patients with ASA Score above 3 * Patients with obstructive (FEV1\<%60) or restrictive pulmonary disease (FVC\<%60) * Patients with intrathoracic operation history * Heavy smokers (\>25 cigarettes/day)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The difference between LUS Scores at T5 in patients ventilated with VCV and PCV | (T5) 60 minutes after patients come to the recovery room. | Lung Ultrasonography will be applied to patients after surgery in the recovery room at T5. Two different groups' LUS scores will be calculated and compared. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The difference between LUS Scores at T2 in patients ventilated with VCV and PCV | (T2) 5 minutes after intubation | Lung Ultrasonography will be applied to patients after intubation. Two different groups' LUS scores will be calculated and compared. |
| The difference between LUS Scores at T3 in patients ventilated with VCV and PCV | (T3) 5 minutes after the surgical procedure is finished | Lung Ultrasonography will be applied to patients at Trendelenburg position after the surgical prosedure is finished. Two different groups' LUS scores will be calculated and compared. |
| The difference between LUS Scores at T4 in patients ventilated with VCV and PCV | (T4) 5 minutes after taking the patient to supin position | Lung Ultrasonography will be applied to patients at supin position after the surgical prosedure is finished. Two different groups' LUS scores will be calculated and compared. |
Countries
Turkey (Türkiye)
Contacts
Primary ContactHacer Zeynep Turgut, MD
Backup ContactFatis Altintas, MD
Outcome results
None listed