Modeling of the Hemoglobin Drop in the Uncomplicated Postoperative Course

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03740438

Enrollment

154

Registered

2018-11-14

Start date

2018-09-01

Completion date

2023-09-02

Last updated

2024-10-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative/Postoperative Complications, Surgery, Surgical Blood Loss

Keywords

Hemoglobin, Hemoglobin drop, Surgical Blood loss

Brief summary

transfusion-related decisions in the perioperative setting are often complex due to acute variations in the hemoglobin levels, which typically experience a progressive decrease within days. This process, commonly referred to as hemoglobin drop or hemoglobin drift, has been observed to be highly variable among patients and reliant on several variables, such as the volemic status, fluid balance and blood loss. Although it has been investigated and some predictors have been identified, postoperative hemoglobin drop remains unpredictable and is not fully clarified. In consequence, hemoglobin levels' variations are frequently misunderstood, hindering the decision to transfuse.

Interventions

DIAGNOSTIC_TESTHemoglobin concentration

Perioperative hemogloin concentration

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adult patients electively scheduled for laparoscopic urologic and gynecologic surgery.

Exclusion criteria

* Suspected or confirmed coagulopathy (including current treatment with anticoagulants or antiplatelet agents). * Requirement for surgical gauzes during surgery, including conversion to open surgical techniques. * Transfusion of red blood cells (RBCs) or use of blood recovery systems during the perioperative period. * Significant postoperative bleeding (\> 50 ml in surgical drains, gross hematuria, or any other type of significant blood loss). * Postoperative hemodynamic instability (defined as requirement of vasoactive drugs). * Other major postoperative complications during the observable period.

Design outcomes

Primary

Measure	Time frame	Description
Hemoglobin concentration	2-5 days	Patient´s hemoglobin concentration in the postoperative course (measured every 24 hours)

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026