Effects of Repetitive Transcranial Magnetic Stimulation on Heart Rate Variability

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03739489

Acronym

TMSXHRV

Enrollment

Registered

2018-11-13

Start date

2018-04-01

Completion date

2018-12-31

Last updated

2018-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Rate Variability

Keywords

healthy subjects, repetitive transcranial magnetic stimulation, heart rate variability

Brief summary

Repetitive transcranial magnetic stimulation is a non-invasive neuromodulation technique used to treat different neuropsychiatric disorders, such as, depression, neuropathic pain, fibromyalgia and obsessive-compulsive disorder. It is known that the heart rate variability is altered in these conditions. Therefore the focus of this research is to show the influence of rTMS on the Heart Rate Variability.

Interventions

PROCEDURERepetitive transcranial magnetic stimulation

Repetitive transcranial magnetic stimulation was a technique able to modulate the brain circuit restoring the function.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Intervention model description

The participant will be received three different sessions of rtms, with wash out 30 days between sessions.

Eligibility

Sex/Gender

ALL

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Agreed participate the protocol * Signing the consent form * Do not present any cardiac problems or disease

Exclusion criteria

* Trauma of Skull, epilepsy don't treated, * Use of medications decrease the seizure threshold * Patients in use of drugs, how cocaine and alcohol * Neurosurgical clips, pacemakers, increased intracranial pressure (risk of sequelae after seizure) * Pregnant or breastfeeding women

Design outcomes

Primary

Measure	Time frame	Description
Heart rate variability changes	Three times during the entire study. Following the scheme, Until 1 hour before each session, 15 minutes along the each session and until 1 hour after the end of session	Changes in heart rate variability measured by Polar V800

Secondary

Measure	Time frame	Description
Conditioned Pain Modulation	48 hours before the first session of stimulation	change in pain units on a scale of 0-100. 0 no pain. 100 = the maximum pain
Volume in	1 week before the first session of stimulation	Determine if volume cortical regions can serve as biomarkers to predict rTMS treatment response in Healthy volunteers

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026