Early Diagnosis, Exosomes, High Grade Serous Carcinoma, Ovarian Cancer, Prognosis
Conditions
Brief summary
This study aims to analyze the expression of micro-RNA (miRNA) and long non-coding RNA (lncRNA) by next-generation sequencing in patients with high grade serous ovarian cancer (HGSOC) and benign gynecologic diseases. The candidate miRNA/lncRNA will be validated as biomarker for the detection and prognosis of HGSOC.
Interventions
GENETICSequencing of miRNA/lncRNA
Next generation sequencing of micro-RNA (miRNA) and long non-coding RNA (lncRNA)
Sponsors
Lei Li
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Confirmed primary high grade serous ovarian cancer * Willing to accepted debulking surgeries and adjuvant chemotherapy * Good performance status * Aged 18 years or older * Signed an approved informed consents
Exclusion criteria
* Not meeting all of the inclusion criteria
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differential expression of miRNA/lncRNA | One year | Differential expression of micro-RNA (miRNA) and long non-coding RNA (lncRNA) will be compared between HGSOC group and control group, hence candidate miRNA/lncRNA will be validated as biomarker for the detection and prognosis of HGSOC. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Progression-free survival | Five years | The progression-free survival of HGSOC patients will be compared between differential expressed candidate miRNA/lncRNA after they have completed debulking surgeries and adjuvant chemotherapy. |
Countries
China
Contacts
Primary ContactLei Li, M.D.
Outcome results
None listed