Hemorrhage
Conditions
Brief summary
Assessment of pulp inflammation by hemostasis achievement after pulp exposure
Detailed description
The possibility has been raised of diagnosing pulpal pathological status using the cytokines that are released during the inflammation process in healthy as well as infected tooth pulp. Cytokines are small polypeptides secreted by leucocytes and other inflammatory cells and are known to play important roles in the intensity and duration of the immune response
Interventions
DIAGNOSTIC_TESTENzyme linked immunity-sorbet assays
Hemostasis achievement reflecting inflammatory status of the pulp based on cytokine levels
Sponsors
Cairo University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
5 Years to 7 Years
Healthy volunteers
No
Inclusion criteria
1. healthy children 2. patients had not used any inflammatory medications 3. primary molar teeth of these children were included based on the following clinical and radiographic criteria: 1. no clinical symptoms or evidence of pulp degeneration (pain on percussion, history of swelling or sinus tract 2. no spontaneous pain 3. no radiographic signs of internal or external resorption, widened periodontal ligament space, or furcal/periapical radiolucency 4. physiological root resorption of no more than one third the root length 5. a deep caries lesion with a likelihood of pulp exposure during caries removal
Exclusion criteria
* patients used any anti-inflammatory medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measuring interleukin 2 (IL-2) | After 5 minutes | to measure cytokines levels after coronal pulpal removal |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measuring interleukin 6 (IL-6) and interleukin 8 (IL-8) | After 5 minutes | to measure cytokines levels after coronal pulpal removal |
| Postoperative pain, Bifurcation/periapical radiolucency and Internal/external root resorption Or other pathological changes | 3,6,9,12 months | To assess postoperative pain by verbal questioning and To observe presence or absence of radiolucency and root resorption or pathological condition |
Countries
Egypt
Outcome results
None listed