Acute Leukemia
Conditions
Brief summary
Descriptive study of acute leukemia patients. Bone marrow aspirate or peripheral blood samples will be analyzed by next-generation sequencing for novel gene signatures and variations in transcriptional and epigenetic regulatory elements such as ARID5B and SALL4 variants.
Interventions
DIAGNOSTIC_TESTBone marrow aspirate or peripheral blood sample collection
Collection of specimen samples only
Sponsors
Sanford Health
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Months to 30 Years
Healthy volunteers
No
Inclusion criteria
* Newly diagnosed or relapsed acute leukemia (AML or ALL) * Plan to undergo diagnostic bone marrow aspirate or peripheral blood if clinically indicated (i.e. WBC\>50,000 and bone marrow contraindicated) * Age 1 month to 30 years * Understand and provide informed consent (subject if\>18, legal guardian if\<18)
Exclusion criteria
* Age 0 to 4 weeks * Treatment related leukemia or leukemia secondary to MDS * Situations that would limit compliance with study requirements or ability to willingly give consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ARID5B polymorphism/mutation status | 5 years | Correlation of our experimentally validated Arid5b dependent transcriptional signature with primary patient samples measured by patient ARID5B expression and polymorphisms. |
Countries
United States
Outcome results
None listed