Inflammation, Myocardial Infarction
Conditions
Brief summary
The aim of this research is to study the effect of a loading dose of colchicine on the occurrence of periprocedural myocardial infarction (PPMI) in elective percutaneous coronary intervention.
Interventions
DRUGColchicine Loading Dose
Two milligrams of colchicine will be administrated in addition to the standard of care treatment
DRUGStandard of care treatment prior to elective PCI
All medications normally given to patients prior to elective PCI
Sponsors
Hillel Yaffe Medical Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patients hospitalized with troponin negative events and scheduled for elective PCI
Exclusion criteria
* Significant renal dysfunction * Significant liver dysfunction * Severe left ventricular dysfunction * Severe low weight * Chronic colchicine treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Occurrence of PPMI post elective PCI | 24 hours post PCI | Occurrence of PPMI post elective PCI and its relation to defensin levels |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Traditional inflammatory markers | 24 hours post PCI | Determination of traditional inflammatory markers including c-reactive protein, white blood cells and interleukin-6 |
| Major adverse cardiovascular events | 30 days | Determining the occurrence of major adverse cardiovascular events |
Countries
Israel
Contacts
Primary ContactRami Abu Fanne, MD, PhD
Outcome results
None listed