Neutrophil Extracellular Traps; Antiphospholipid Antibody-induced Pregnancy Loss
Conditions
Brief summary
1. Establish a multi-platform detection system for neutrophil extracellular traps in blood and tissues, and evaluate the detection performance; 2. Comparing the expression levels of neutrophil extracellular traps in peripheral blood and decidua of patients with antiphospholipid antibody-induced pregnancy loss and normal control group; 3. Comparing the expression levels of neutrophil extracellular traps in peripheral blood and decidua of mice with antiphospholipid antibody-induced pregnancy loss and normal control group; 4. After treatment of antiphospholipid antibody-induced mouse abortion model with metformin,the effect of metformin on embryo loss rate and viable embryo body weight was observed.
Interventions
None listed
Sponsors
Shanghai First Maternity and Infant Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
25 Years to 41 Years
Healthy volunteers
Yes
Inclusion criteria
* Clinical diagnosis of Recurrent spontaneous abortion * Clinical diagnosis of Antiphospholipid syndrome
Exclusion criteria
* Other autoimmune diseases * Hematopoietic system diseases * Cardiovascular system diseases * Gastrointestinal system diseases * Urinary system diseases * Nervous system or mental diseases * Have taken other drugs recently
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| NETs level | through study completion, an average of 8 months | Neutrophil extracellular traps (NETs) are networks of extracellular fibers, primarily composed of DNA from neutrophils, which bind pathogens. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| complete blood count (CBC) | through study completion, an average of 8 months | CBC is a blood panel requested by a doctor or other medical professional that gives information about the cells in a patient's blood, such as the cell count for each blood cell type and the concentrations of hemoglobin. |
Other
| Measure | Time frame | Description |
|---|---|---|
| C3 level | through study completion, an average of 8 months | Complement component 3, often simply called C3, is a protein of the immune system. It plays a central role in the complement system and contributes to innate immunity. |
Countries
China
Contacts
Primary ContactShihua Bao
Outcome results
None listed