Evaluations
Conditions
Keywords
Platelet rich plasma, Intrauterine infusion, Thawed embryos, IVF/ICSI cycles
Brief summary
All patients prepared to thawed embryo transfer were classified into 2 groups one group will receive platelet rich plasma (PRP) infusion intrauterine and the other group will not receive platelet rich plasma (PRP) infusion
Detailed description
Patients candidates for Thawed embryo transfer with Repeated implantation failure were recruited from 3 centers and classified into 2 groups: Group I: Will receive platelet rich plasma (PRP) intrauterine infusion at day 11 Group II: Not receiving platelet rich plasma (PRP)
Interventions
platelet rich plasma will be prepared, activated then infused by Intrauterine insemination catheter intrauterine at day 11
BIOLOGICALNormal saline
Intrauterine infusion of normal saline at day 11
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Intervention model description
2 groups parallel
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Patients age 20-35 years * Patients with previous implantation failure * Patients with thin endometrium\<7 mm
Exclusion criteria
* Patients older than 40 years * Patients with fresh embryo transfer * Patients with abnormal uterine cavity septate, or bicornuate uterus * Patients with abnormal male factor or tubal factor * Patients with abnormal embryos grade B or C. * Patients with immunological disorders as thyroidits or systemic lupus or rheumatoid arthritis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Endometrial thickness | 8 days | The increase in endometrial thickness at day of ET |
| Pregnancy rate | 15 days | Number of cases who got pregnant |
Countries
Egypt
Outcome results
None listed