Fertilization in Vitro
Conditions
Brief summary
To investigate the effect of Plasticizer metabolites concentration on the in vitro fertilization outcomes
Detailed description
This study was conducted in a medical center in southern Taiwan. 80 infertile female patients, aged 30 to 40 years old with normal ovarian function, receiving IVF treatment in the infertility outpatient were enrolled in this study. The participates were divided into two groups: successful pregnancy in the IVF cycle (n = 40) and non-pregnancy in the IVF cycle (n = 40). After getting the consent of the patients, we plan to do a questionnaire survey. Additionally, environmental dust and urine were sampled and analyzed the concentration of plasticizers metabolites.The aim of this study is to investigate the effect of Plasticizer metabolites concentration on the in vitro fertilization outcomes.
Interventions
OTHERPhthalate metabolites measurement
To measure phthalate metabolites of urine and house dust in Pregnancy and Non-pregnancy groups
Sponsors
Kaohsiung Veterans General Hospital.
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
30 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Infertile women undergoing in vitro fertilization cycles * Normal ovarian reserve (AMH \> 1.0 and AFC ≧ 5)
Exclusion criteria
* Daily homestay time \> 12 hrs * Diminished ovarian reserve (AMH ≦ 1.0 or AFC\<5) * Oophorectomy * Gynecologic cancer patients * Severe male infertility
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Phthalate of urine | through study completion, an average of 1 year | Phthalate metabolites concentrations |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Phthalate of environmental dust | through study completion, an average of 1 year | Phthalate metabolites concentrations |
Countries
Taiwan
Outcome results
None listed