Newly Diagnosed Multiple Myeloma
Conditions
Keywords
Multiple Myeloma, Front-line, Maintenance therapy
Brief summary
This is a randomized, Phase 2 study involving two arms evaluating the efficacy and safety of ixazomib alone and the combination of both ixazomib and lenalidomide as maintenance therapy for patients with multiple myeloma who have achieved at least partial response (PR) or better after receiving a bortezomib- and lenalidomide-containing combination front-line therapy.
Detailed description
Patients who have achieved PR or better on a bortezomib- and lenalidomide-containing combination therapy will be randomized to receive maintenance therapy with 28-day cycles of either ixazomib alone or the combination of ixazomib and lenalidomide. If steroids were part of the patient's qualifying regimen, steroids will be administered using the same drug(s), schedule(s) and dose(s) as those of the last treatment cycle of the bortezomib-, lenalidomide- and steroid-containing regimen. Ixazomib will be administered per orem (PO) at 3 mg on days 1, 8 and 15 of 28-day cycles. Lenalidomide will be taken PO, once daily at the same dose as the last treatment on days 1 through 28 of the 28-day cycles. Patients will start the randomized maintenance therapy after receiving a minimum of 6 cycles of a bortezomib- and lenalidomide-containing combination treatment but may have received up to 8 cycles if they continued to show improvement in their response after the first 6 cycles. During cycle 1, patients will have clinical laboratory tests weekly (days 1, 8, 15 and 22) and MM disease assessments on day 22 to monitor for efficacy and potential toxicity. Beginning with cycle 2, patients will have clinical laboratory tests performed twice a month and MM disease assessments once a month. Patients will be treated until documentation of PD or if subject meets any of the treatment discontinuation criteria.
Interventions
DRUGIxazomib
3 mg oral capsule, Days 1, 8 and 15 of 28-day cycles
DRUGLenalidomide
Same dose as in the front-line treatment in the last treatment cycle, taken orally, on days 1-28 of a 28-day cycle.
Sponsors
Takeda
Oncotherapeutics
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
A randomized, open label, Phase 2 study involving two arms evaluating the efficacy and safety of ixazomib monotherapy (with steroids if applicable) and the combination of ixazomib and lenalidomide (with steroids if applicable) as maintenance therapy for patients with MM who have achieved at least PR after receiving a bortezomib and lenalidomide (with steroids if applicable)-containing combination frontline therapy.
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
\- Each patient must meet all of the following inclusion criteria to be enrolled in the study: 1. Male or female patients 18 years or older. 2. Patients must be receiving a frontline bortezomib- and lenalidomide-containing regimen for treatment of disease 3. Patients must meet the following clinical laboratory criteria: * Absolute neutrophil count (ANC) grater or equal 1,000/mm3 and platelet count greater or equal 75,000/mm3. Platelet transfusions to help patients meet eligibility criteria are not allowed within 7 days prior to screening platelets or at investigator's discretion. * Hemoglobin ≥ 8.0 g/dL. Use of erythropoietic stimulating factors and red blood cell (RBC) transfusions per institutional guidelines is allowed; however, most recent RBC transfusion must have been at least 7 days prior to obtaining screening hemoglobin or at investigator's discretion. * Total bilirubin less or equal 1.5 times the upper limit of the normal range (ULN). * Calculated or measured creatinine clearance greater or equal 30 mL/min. Calculation is based on a standard Cockcroft and Gault formula (Section 14.2). * AST (SGOT) and ALT (SGPT) less or equal 3 x ULN or less or equal 5 x ULN if hepatic metastases are present. * LVEF ≥ 40%. 2-D transthoracic echocardiogram (ECHO) is the preferred method of evaluation. Mitigated Acquisition Scan (MUGA) is acceptable if ECHO is not available. 4. Patients must be transplant ineligible as determined by the treating physician. 5. Patients must have a life-expectancy of more than 6 months. 6. Patients must have a confirmed diagnosis of MM. 7. Patients receiving front-line therapy must have achieved at least PR and have completed at least 6 cycles of treatment. 8. The disease must have reached a plateau phase at the end of front-line treatment as demonstrated bythe same response (using IMWG criteria) in three consecutive tests with at least three weeks between each test. 9. Patients must have received frontline treatment within 8 weeks of enrollment. 10. Patient can adhere to the study visit schedule and other protocol requirements. 11. Patient Eastern Cooperative Oncology Group (ECOG) performance status is ≤ 2. 12. Patients must voluntarily give written consent before any study related procedure not part of standard medical care is performed, with the understanding that consent may be withdrawn by the patient at any time without prejudice to future medical care. 13. Female patients must be postmenopausal for at least 1 year before screening visit OR surgically sterile. If patient is female of childbeating potential (FCBP), patient must agree to practice two effective methods of contraception, at the same time, from the time of signing the informed consent form through 90 days after the last dose of study drug. FCBP must also adhere to the guidelines of any treatment-specific pregnancy prevention program AND agree to practice true abstinence when this is in line with the preferred and usual lifestyle of the subject. Periodic abstinence (e.g. calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception. 14. Male patients, even if surgically sterilized (i.e., status post-vasectomy), must agree to one of the following: * To practice effective barrier contraception during the entire study treatment period and through 90 days after the last dose of study drug * To practice true abstinence when this is in line with the preferred and usual lifestyle of the subject. Periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception.
Exclusion criteria
* Patients meeting any of the following
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PFS | Through study completion, approximately 5 years | Progression Free Survival |
| Adverse events (AEs) | throughout the study completion, approximately 5 years | Monitoring safety and tolerability via monitoring adverse events graded by CTCAE v5 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| OS | from time of initiation of maintenance therapy to death from any cause or last follow-up visit, up to 60 months | Overall survival |
| Deepening of the response | throughout the study, up to 60 months | define as the percentage of patients who improved their response during maintenance therapy. |
Countries
United States
Outcome results
None listed