Mini-fluid Challenge in Video-Assisted Thoracic Surgery
Conditions
Brief summary
Perioperative fluid management is crucial for patients' outcome. Muller et al developed a Mini-fluid challenge method to predict fluid responsiveness and the efficacy. The investigators design the study to investigate the effectiveness of mini-fluid challenge test in video assisted thoracic surgery.
Detailed description
Perioperative fluid management is crucial for patients' outcome. Series of studies have indicated that adequate fluid management optimizes the cardiac out put, improves tissue perfusion, thus decrease the risk of postoperative morbidity. Muller et al developed a Mini-fluid challenge method to predict fluid responsiveness and the efficacy. Fluid status and proper perfusion condition in patients undergo thoracic surgery are especially crucial for the vulnerability of lung toward fluid overload. To the best of our knowledge, the efficacy of the test was not discussed in the perioperative care in video assisted thoracic surgery. The investigators design the study to investigate the effectiveness of mini-fluid challenge test in video assisted thoracic surgery.
Interventions
Mini-fluid challenge with crystalloid 250 ml will be given to patients first. After observation of hemodynamic parameters, further fluid challenge will be given for response observation.
Sponsors
National Taiwan University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients receiving scheduled video assisted thoracic surgery * BMI 18.5\ 30 kg.m-2
Exclusion criteria
* age younger then 20 yrs or elder than 80 yrs * pregnant women * patients in intensive care units * patients with the underlying disease including respiratory failure(FEV1/FVC \< 70 % and FEV1 \< 50%), heart failure(NYHA score =III、IV), kidney failure(eGFR\< 60 ml.min-1.1.73m-2), liver failure * patients with ongoing infection * patient allergic to voluven
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of blood pressure after fluid loading | 3 hours | Interpretate the correlation of mini-fluid challenge and conventional fluid challenge |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of cardiac index after fluid loading | 3 hours | Interpretate the correlation of mini-fluid challenge and conventional fluid challenge |
Other
| Measure | Time frame | Description |
|---|---|---|
| stroke volume index(SVI) | 3 hours | Interpretate the correlation of mini-fluid challenge and conventional fluid challenge |
| stroke volume variation(SVV) | 3 hours | Interpretate the correlation of mini-fluid challenge and conventional fluid challenge |
| pulse pressure variation(PPV) | 3 hours | Interpretate the correlation of mini-fluid challenge and conventional fluid challenge |
| plethysmographic variation index(PVI) | 3 hours | Interpretate the correlation of mini-fluid challenge and conventional fluid challenge |
| stroke volume (SV) | 3 hours | Interpretate the correlation of mini-fluid challenge and conventional fluid challenge |
Countries
Taiwan
Contacts
Primary ContactTzu Jung Wei
Backup ContactNational Taiwan University Hospital
Outcome results
None listed