Iodine Deficiency
Conditions
Keywords
Iodine, Urinary iodine concentration
Brief summary
Iodine status in populations is assessed using urinary iodine concentration (UIC) measured in spot urine samples. The iodine intake is classified as deficient, sufficient, or excessive iodine based on the median UIC (mUIC). However, this approach has limitations, as it does not quantify the prevalence of individuals with habitually deficient or excess iodine intakes. The EAR cut-point method has the potential to quantify prevalence of iodine deficiency and excess. However, little is known about the effects of the inter- and intra-individual variance of UIC. The aim of the study is to quantify the intra-individual variability in dietary iodine intake. The overall goal is to estimate the prevalence of iodine deficiency and excess in the study population and propose sample size recommendations for future iodine nutrition population studies. The results will provide evidence guiding international recommendations for iodine nutrition studies.
Interventions
OTHERNo intervention
This is an observational study and no interventions will be administered.
Sponsors
Swiss Federal Institute of Technology
Study design
Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 44 Years
Healthy volunteers
Yes
Inclusion criteria
* Non-pregnant * Non-lactating * Non-smoking * Residence in Switzerland ≥12 months * Generally healthy * No family history of goiter * No exposure to iodine containing contrast agents during the last 12 months - Informed consent given
Exclusion criteria
* Participant is not able to understand the study information or procedure, e.g. due to linguistic barriers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Estimated daily urinary iodine excretion | 7 days | Estimated urinary iodine excretion (µg/day) will be obtained from urinary iodine concentration (UIC) and urinary creatinine concentration (UCC) measured in two repeat spot urine samples collected within 7 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Thyroid function test Tg | 1 day | Tg concentration (µg/L) measured in dried blood spots |
| Measured daily iodine excretion | 1 day | Measured daily iodine excretion (µg/day) will be obtained from urinary iodine concentration (UIC) and urine volume in a 24 h urine collection |
| Thyroid function test TSH | 1 day | TSH concentration (mU/L) measured in dried blood spots |
| Thyroid function test total T4 | 1 day | Total T4 concentration (nmol/L) measured in dried blood spots |
Countries
Switzerland
Outcome results
None listed