Muscle Synergies After Stroke

Are Spatial and Temporal Muscle Synergy Modules Related to Functional Ability After Stroke?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03731299

Enrollment

114

Registered

2018-11-06

Start date

2015-04-01

Completion date

2017-12-01

Last updated

2018-11-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Keywords

muscle synergies, gait, functional ability

Brief summary

The aim of this systematic review was to determine the number of muscle synergies and the distribution of muscle weightings in stroke patients during gait.

Detailed description

The aim of this systematic review was to determine the number of muscle synergies and the distribution of muscle weightings in stroke patients during gait. Although literature has suggested that merging of synergies occurs after stroke and that a larger number of is associated with increased motor function if compared with healthy adults. IIt is still unknown if this hypothesis is also relevant when comparing different functional levels within a stroke population and what functional impact of altered synergies on walking behavior is.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

Stroke: 1. haemorrhagic or ischaemic stroke diagnosis, confirmed on the basis of CT or MRI imaging; 2. no known history of previous stroke; 3. stroke onset within five months; 4 patients are between 18 and 85 years of age;

Exclusion criteria

Stroke: 1. A score of 20 or higher on the Trunk Impairment Scale which indicates normal truncal function; 2. A score lower than two on the Functional Ambulation Categories (FAC) as patients needed to be able to ambulate without physical support to ensure that gait analysis can be executed safely; 3. Not able to sit independently for 30 seconds on a stable surface; 4. They suffer from other neurological and orthopaedic disorders that could influence motor performance and balance; 5. not able to understand instructions.

Design outcomes

Primary

Measure	Time frame	Description
Amount of muscle synergies derived by non-negative matrix factorization	Once, in the week of inclusion	Spatial characteristic of muscle synergy compared to healthy adults: the amount of synergies during walking in stroke subjects, the amount of muscles in one synergie and which muscles in one synergy

Secondary

Measure	Time frame	Description
Distribution of muscle synerigies derived by non-negative matrix factorization	Once, in the week of inclusion	Temporal characteristic of muscle synergy compared to healthy adults: When are these synergies active during the gait cycle (100%).

Outcome results