Exercise Training, Insulin Resistance, Obesity, Type2 Diabetes
Conditions
Brief summary
Obesity and insulin resistance are worldwide epidemic and taking a major public health toll. Obesity also increases the risk for cognitive impairment which is also an increasing medical, societal, and economic challenge. The ultimate goal of this proposal is to develop a statistical model to assess systemic cross-talk between brain, peripheral tissues, gut microbiota and glucose metabolism. Integrated with exercise training intervention the results will be utilized to provide disease risk profiling and personalized predictions of exercise training as a drug free treatment for insulin resistance and type 2 diabetes.
Interventions
BEHAVIORALExercise training
Subjects are required to exercise four times a week during six months. Exercise training consists of endurance training, resistance training and high-intensity interval training adjusted to subject's fitness level.
Sponsors
University of Helsinki
University of Eastern Finland
Turku University Hospital
Academy of Finland
Finnish Cultural Foundation
Diabetes Research Foundation, Finland
Juho Vainio Foundation
University of Turku
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
Exercise Training for six months
Eligibility
Sex/Gender
ALL
Age
30 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* monozygotic twins * body mass index (BMI) difference ≥ 2 kg/m2 and/or type 2 diabetes * At least one co-twin is overweight (BMI \> 25 kg/m2)
Exclusion criteria
* BMI \> 60 kg/m2 * body weight \> 170 kg * waist circumference \> 150 cm * mental disorder or poor compliance * eating disorder or excessive use of alcohol * active ulcus disease * diabetes requiring insulin treatment or fasting glucose \> 10 mmol/l * pregnancy * past dose of radiation * claustrophobia * presence of ferromagnetic objects that would make MRI contraindicated
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effects of exercise training - brain glucose uptake | The change from baseline to 6 months | Brain glucose uptake (micromol/100g/min) is measured with positron emission tomography (PET) with \[18F\]-labelled fluoro-deoxy-glucose (FDG) tracer. |
| Effects of exercise training - brain inflammation | The change from baseline to 6 months | Brain inflammation (dimensionless; standistibution volume ratio) is measured with positron emission tomography (PET) with PK11195 tracer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effects of exercise training - liver glucose uptake | The change from baseline to 6 months | Liver glucose uptake (micromol/100g/min) is measured with positron emission tomography (PET) with \[18F\]-labelled fluoro-deoxy-glucose (FDG) tracer |
| Effects of exercise training - adipose tissue glucose uptake | The change from baseline to 6 months | Adipose tissue glucose uptake (micromol/100g/min) is measured with positron emission tomography (PET) with \[18F\]-labelled fluoro-deoxy-glucose (FDG) tracer |
| Effects of exercise training - whole-body insulin sensitivity | The change from baseline to 6 months | Whole-body insulin sensitivity (M-value; micromol/100g/min) during the hyperinsulinemic euglycemic clamp |
| Effects of exercise training - ectopic fat | The change from baseline to 6 months | Ectopic fat content (%) is measured using magnetic resonance spectroscopy (MRS) |
Countries
Finland
Outcome results
None listed