Microcirculation in Patients With Leukemic Hyperleukocytosis

Visualization of Microcirculation in Patients With Leukemic Hyperleukocytosis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03729206

Enrollment

Registered

2018-11-02

Start date

2018-08-01

Completion date

2021-08-01

Last updated

2022-11-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyperleukocytic Syndrome

Brief summary

Hyperleukocytosis in patients with acute leukemia impacts rheology and microvascularization, leading to severe symptoms or even death. The investigators investigated whether blood stream alterations induced by hyperleukocytosis can be detected by sidestream dark-field imaging and whether they correlate with the grade of symptoms.

Interventions

DIAGNOSTIC_TESTintravital microscopy

intravital microscopy with sidestream dark-field imaging

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* acute leukemia * de-novo or relapsed stage * able to give consent

Exclusion criteria

* severe oral mucositis * unable to give consent * pregnant women * patients hospitalized for psychiatric disease

Design outcomes

Primary

Measure	Time frame
microvascular flow index (MFI) of sublingual microcirculation	24 months

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026