Effects of a Liquid Meal and Gut Hormones (GIP and GLP-2) on Bone Remodeling in Participants With Hypoparathyroidism.

Effects of a Liquid Meal and Gut Hormones (GIP and GLP-2) on Bone Remodeling in Participants With Hypoparathyroidism (KS-4-HypoPT).

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03728959

Acronym

KS-4-HypoPT

Enrollment

Registered

2018-11-02

Start date

2018-09-12

Completion date

2019-04-12

Last updated

2019-12-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypoparathyroidism

Keywords

hypoparathyroidism, Glucose-dependent insulinotropic polypeptide (GIP), Glucagon-like peptide-2 (GLP-2), Bone remodeling, Bone resorption, Bone formation, C-terminal telopeptide (CTX), N-terminal propeptide of type 1 procollagen (P1NP)

Brief summary

Hypoparathyroidism (hypoPT) is characterized by low levels of PTH. In this study we will test the effects of a liquid meal on the bone remodeling in participants with hypoparathyroidism. Furthermore, we will test the effects of the gut hormones GIP and GLP-2.

Interventions

OTHERLiquid meal (Nutridrink)

Liquid meal ingested over 1 minute.

OTHERGIP

Subcutaneous injected GIP

OTHERGLP-2

Subcutaneous injected GLP-2

OTHERPlacebo (saline)

Subcutaneous injected Placebo (saline)

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 76 Years

Healthy volunteers

Inclusion criteria

* Age between 18 and 76 * Hypoparathyroidism

Exclusion criteria

* Diabetes * Disease in the gastrointestinal tract * Antiosteoporotic drug * Long term steroid treatment (within the last 12 months) * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Serum concentration of C-terminal telopeptide (CTX)	-10 to 240 minutes	Marker of bone resorption, measured in serum
N-terminal propeptide of type 1 procollagen (P1NP)	-10 to 240 minutes	Marker of bone formation, concentration measured in serum

Secondary

Measure	Time frame	Description
C-peptide	-10 to 240 minutes	C-peptide concentration measured in serum
Glucose	-10 to 240 minutes	Glucose concentration measured in serum
Insulin	-10 to 240 minutes	Insulin concentration measured in serum
PTH	-10 to 240 minutes	PTH concentration measured in serum
Glucose-dependent insulinotropic polypeptide (GIP)	-10 to 240 minutes	Gut hormone, concentration measured in plasma
Glucagon-like peptide-2 (GLP-2)	-10 to 240 minutes	Gut hormone, concentration measured in plasma
Glucagon-like peptide-1 (GLP-1)	-10 to 240 minutes	Gut hormone, concentration measured in plasma

Other

Measure	Time frame	Description
Heart rate	-10 to 240 minutes	Heart rate measured before blood sampling
Blood pressure	-10 to 240 minutes	Blood pressure (systolic and diastolic) measured before blood sampling

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026