TIVA Versus Desfluran Anaesthesia in Patients Undergoing Bariatric Surgery

A Randomized Controlled Trial - Total Intravenous Anaesthesia Versus Inhaled Desfluran Anaesthesia in Patients Undergoing Bariatric Surgery. Postoperative Pain and Nausea

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03727607

Enrollment

160

Registered

2018-11-01

Start date

2016-01-30

Completion date

2018-03-14

Last updated

2018-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Desflurane, Nausea, Postoperative, Obesity, Pain, Postoperative, Total Intravenous Anesthesia

Brief summary

Many factors during laparascopic surgery leads to PONV (postoperative nausea and vomiting), such as C02 insufflations causing peritoneal stretch and irritation and type of anaesthesia given during surgery. The two anesthetic techniques used in bariatric surgery are gas anesthesia (Remifentanil TCI and Desfluran) and Total Intra Venous Anesthesia (TIVA) with propofol. There are studies which have shown a reduction in postoperative nausea and vomiting following TIVA, and there are publications showing no statistically significant difference. The aim of this study was to investigate the best anaesthetic approach for obese subjects, evaluating awakening time, postoperative nausea and pain. Our hypothesis was based on the fact that Propofol is a lipid-soluble anesthetic and therefore might have a prolonged effect in obese patients, leading to a longer awakening time along with postoperative nausea and vomiting. This hypothesis is also described earlier by obese patients have more depots (bulk fat) and also more fat surface making anaesthetics storage more easier, and also that the anesthetic will return into the circulation when the administration is stopped \[18\].

Interventions

DRUGDesflurane

Desflurane vs TIVA, bariatric surgery. Postoperative nausea and pain

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Intervention model description

randomized control trial.

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* BMI ≥35 kg/m2 with at least one comorbid condition or BMI ≥40 kg/m2.

Exclusion criteria

* drug abuse * severe mental illness * age\<18 * serious medical condition; cancer, end-stage lung disease (ASA\>3) or allergies to any drugs used in the study

Design outcomes

Primary

Measure	Time frame	Description
Awakening time after surgery	2 hours postdose	time noted from anaesthesia stoped to patients awake
Degree of nausea and vomiting after surgery	48 hours postsurgery	Noted using NRS scale (from 0-10)
Degree of pain after surgery	48 hours post surgery	Noted using NRS scale (from 0-10)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026