Effects of Replacing Diet Beverages With Water on Weight Maintenance of Type 2 Diabetic Obese Women: 18 Months Follow up

Effects of Replacing Diet Beverages With Water on Type 2 Diabetic Obese Females Attending a Weight Loss Program - a Randomized, 24 Week Clinical Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03726762

Enrollment

Registered

2018-10-31

Start date

2015-04-30

Completion date

2017-06-30

Last updated

2018-10-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obese, Overweight, Type 2 Diabetes

Keywords

diet beverages, water, diabetes, weight loss, insulin sensitivity

Brief summary

the present study aimed to follow up our participants in order to consider the changes in weight and anthropometric measurements after the 12-month weight maintenance as well as the total of 18 months, consisting of the previously described 24 weeks active weight loss and a further 53 weeks weight maintenance. The secondary outcome was to compare the abdominal adiposity, carbohydrate, and lipid metabolism during these periods.

Interventions

BEHAVIORALDBs at the end of the main meal + weight control program

Subjects are asked to have 250 ml DBs at the end of their lunch as the main meal, while they are on a multidisciplinary diet plan.

BEHAVIORALWater at the end of the main meal+ weight control program

Subjects are asked to have 250 ml water at the end of their lunch as the main meal, while they are on a multidisciplinary diet plan.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

* Diabetic female patient with 6.5\<H1AC\<7.2. * Monotherapy with Metformin. * 18-45 years of age. * Body mass index (BMI) between 27-35 kg/ m². * Consume DBs regularly during their habitual diet. * Must be able to have moderate exercise. * Must be interested to have weight loss.

Exclusion criteria

* Participating in a research project involving weight loss or physical activity in the previous six months. * Pregnancy or lactation during the previous 6 months, or planned pregnancy in the next six months. * Taking medication that could affect metabolism or change body weight. * Report heart problems, chest pain, and cancer within the last five years. * Unwilling to change intake of beverages during the study period.

Design outcomes

Primary

Measure	Time frame
Weight loss	77 weeks

Secondary

Measure	Time frame
Insulin resistance (HOMA)	77 weeks
Lipid profiles	77 weeks
Fasting plasma glucose	77 weeks
BMI	77 Weeks
HA1C	77 Weeks
Waist circumference	77 weeks

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026