Takotsubo Syndrome
Conditions
Brief summary
Aim of this prospective study is to assess the pathophysiology of Takotsubo Syndrome by obtaining pressure volume loops with conductance catheters, which allows detailed conclusions regarding systolic and diastolic hemondynamics and subsequently regarding potential underlying mechanisms
Interventions
DIAGNOSTIC_TESTMeasurements of left ventricular pressure and volume
Patients with suspected Takotsubo syndrome (typical ballooning in left ventriculography without significant obstructive coronary artery disease that sufficiently explains the contraction abnormalities) will undergo continuous online measurements of left ventricular pressure and volume using conductance catheters. Cardiac magnetic resonance (CMR) imaging will be performed in patients without contraindications for optimized morphological characterization and exclusion of important differential diagnoses.
Sponsors
University of Luebeck
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Confirmed Takotsubo syndrome according to current diagnostic criteria including complete normalization of left ventricular function during follow-up * Sinus rhythm during invasive measurements * Age ≥18 years * Written informed consent
Exclusion criteria
* Cardiogenic shock * Signs of myocarditis or myocardial infarction with spontaneous lysis of thrombus in cardiac magnetic resonance imaging * Pregnancy * Participation in another trial
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in contractility derived from pressure-volume measurements | Day 0 | systolic/diastolic pressure-volume relationship (mmHg/ml) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Energetic parameters derived from pressure-volume measurements | Day 0 | stroke work, potential energy (mmHg x ml) |
| Afterload parameters derived from pressure-volume measurements | Day 0 | arterial elastance (mmHg/ml) |
| - Correlation of pressure-volume measurements with morphological and functional findings in CMR imaging | Day 3 | (presence of myocardial edema or late gadolinium enhancement, native T1 time, myocardial strain assessed by CMR feature tracking) |
| - Correlation of pressure-volume measurements with biomarker release | Day 0 | (troponin, NT-proBNP) |
Countries
Germany
Outcome results
None listed