Insulin Sensitivity, Glucose Tolerance
Conditions
Brief summary
To examine the differential effect of camel and cow milk on the physiological response, to a liquid mixed-meal challenge, in people with normal glucose tolerance
Detailed description
Camel milk is used as a traditional remedy throughout the Middle East and Indian Subcontinent for conditions such as type 2 diabetes and dyslipidemia. It is currently unclear how such an effect could be mediated in vivo and studies are limited. We performed this study as a pilot experiment to assess the effects of camel milk on Insulin, Glucose, GLP-1, C-peptide and Lipid profile.
Interventions
DIETARY_SUPPLEMENTCamel milk
Camel Milk administered 10 minutes before a mixed meal of carbohydrate and protein; 2-week washout between interventions
DIETARY_SUPPLEMENTCow milk
Cow milk administered 10 minutes before a mixed meal of carbohydrate and protein;2-week washout between interventions
Sponsors
Imperial College London Diabetes Centre
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Masking description
Double-blind
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Normal glucose tolerance * BMI \< 30 kg/m2
Exclusion criteria
* Type 1 diabetes mellitus * Type 2 diabetes mellitus * Impaired fasting glucose or impaired glucose tolerance * Lactose intolerance * Weight loss / gain ≥ 5 kg in the preceding two months * Use of estrogenic drugs or corticosteroids * Known hypertriglyceridemia requiring treatment * History of heart attack, angina or cardiovascular disorder * History of malignant tumor * Pregnant or lactating women * Hemoglobin \< 12 for any reason * Recent surgery or major hemorrhage * History of bariatric or metabolic surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glucose response to camel and cow milk | 5 months | The difference between interventions in terms of peak of glucose |
| Response of glucose to camel and cow milk | 5 months | The difference between interventions in terms of area under the curve |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| GLP-1 response to camel and cow milk | 5 months | The difference between interventions in terms of peak |
| Response of GLP-1 to camel and cow milk | 5 months | The difference between interventions in terms of area under the curve |
| Insulin response to camel and cow milk | 5 months | The difference between interventions in terms of peak |
| Response of C-peptide to camel and cow milk | 5 months | The difference between interventions in terms of area under the curve |
| C-peptide response to camel and cow milk | 5 months | The difference between interventions in terms of peak |
| Response of insulin to camel and cow milk | 5 months | The difference between interventions in terms of area under the curve |
Countries
United Arab Emirates
Outcome results
None listed