Infertility, Female
Conditions
Keywords
Progesterone, Saliva, IVF, Frozen embryo transfer
Brief summary
The aim of this study is to perform a 12-hour profile of free saliva progesterone during the luteal phase after fresh and frozen embryo transfer. If progesterone levels in saliva samples show a constant level during daytime, this non-invasive measurement can be used in future ART patients with insufficient progesterone levels who might benefit from additional exogenous progesterone supplementation.
Interventions
DIAGNOSTIC_TESTProgesterone analysis in saliva
Analysis of salava progesterone
Sponsors
Boston IVF
Peter Humaidan
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-45 years * One or two good quality embryos for transfer on day 5. * BMI \>18,5 \<30 kg/m²
Exclusion criteria
* No good quality embryos for transfer * Uterine abnormalities * One ovary * Oocyte donation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of free progesterone in saliva | 12 hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical pregnancy rate | 8 weeks | Ultrasound detected gestational sack divided with number of embryo transfer |
| Ongoing pregnancy rate | 12 weeks | Viable pregnancy after gestational week 12+0 |
Countries
Denmark
Outcome results
None listed