Symptomatic Irreversible Pulpitis
Conditions
Keywords
Anesthetic efficacy, Inferior alveolar nerve blocks
Brief summary
The aim of this prospective randomized clinical trial was compare between 2% Mepivacaine and 4% Articaine for inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis in mandibular molars as regards to their anesthetic efficiency; during access cavity preparation and instrumentation.
Detailed description
Sixty-six patients diagnosed clinically and radiographically with symptomatic irreversible pulpitis in mandibular posterior teeth will received single-visit root canal treatment using ProTaper Universal rotary system for canal preparation, then they will be randomly divided into two groups (n=33) according to the anesthetic solution used, either Group M (3.6 ml Mepivacaine hydrochloride 2% with 1:100000 epinephrine) or Group A (3.4 ml Articaine hydrochloride 4% with 1:100000 epinephrine). The pain will be assessed using numerical rating scale (NRS) during access cavity preparation and instrumentation, then the need for supplemental anesthesia will be also recorded.
Interventions
DRUGmepivicane hydrochloride
Pain will be assessed during access cavity preparation and instrumentation
DRUGarticane hydrochloride
Pain will be assessed during access cavity preparation and instrumentation
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
1. Patients in good health (American Society of Anesthesiologists Class II or higher) 2. Patients having symptomatic irreversible pulpitis in one of their mandibular molars. 3. Age range is between 20 and 50 years. 4. Patients who can understand Visual Analogue Scales VAS. 5. Patients able to sign informed consent
Exclusion criteria
1. Patients allergic to articaine and/or mepivacaine and/or sulfur 2. Patients having active sites of pathosis in the area of injection. 3. Patients having active pain in more than one molar. 4. Patients who had taken analgesics in the 12 hours preceding the injection.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain intensity: Numerical rating scale (NRS) | Fifteen minutes after injection of the anaesthetic solution | Pain intensity during access cavity preparation using numerical rating scale (NRS). The scale was numerical to facilitate its use by the participants. The Numerical rating scale is an 10-point scale anchored by two extremes No pain and pain as bad as it could be. Pain was categorized into four categorical scores: (1) none \[score 0\], (2) mild \[score from 1-3\], (3) moderate \[score from 4-6\], (4) severe \[score from 7-10\]. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain intensity: Numerical rating scale (NRS) | Twenty-five minutes after injection of the anaesthetic solution | Pain intensity during root canal negotiation and instrumentation using Numerical rating scale is an 10-point scale anchored by two extremes No pain and pain as bad as it could be. Pain was categorized into four categorical scores: (1) none \[score 0\], (2) mild \[score from 1-3\], (3) moderate \[score from 4-6\], (4) severe \[score from 7-10\]. |
| The number of patients who need suplemental anesthesia | Fifteen minutes after injection of the anaesthetic solution | counting the number of the number of patients who need suplemental anesthesia |
Countries
Egypt
Contacts
Primary ContactMarwa M Bedier, PHD
Backup ContactMohamed F Marakby, Master
Outcome results
None listed