Regeneration
Conditions
Brief summary
The majority of articles present in literature concerning the enrollment of tissue engineering in the field of root canal treatment is concerned with the treatment of affected teeth with immature apex, after proper systematic search online, only 4 articles where found that are dealing with the treatment of teeth with mature apex. These 4 studies are case reports. None of these studies has been a randomized clinical trial, the gold standard of interventional trials resulting in the highest level of evidence that contributes effectively in the clinical decision-making process as to the best intervention for the patient's condition providing the most effective clinical outcomes for the satisfaction of the patient. Since that the triad of regenerative endodontics are the key of success of any attempt to regenerate pulp, 2 different maneuvers shall be done in this study.
Detailed description
Preservation of the natural dentition had always been a primary objective in endodontic practice. When the pulp is diseased or requires removal for restorative reasons, it is replaced with an artificial filling material during conventional root canal treatment. Root canal treatment has lots of drawbacks, starting with different iatrogenic errors during endodontic procedures, weakening of remaining tooth structure which might affect the tooth survival. Also Root canal treated teeth require the placement of a post and core, which itself is doubtful whether it increases fracture resistance of the tooth or it weakens it. The most important drawback is that the survival of affected pulp is hindered by the conventional root canal treatment. Thus a new treatment approach was introduced utilizing the body ability to regenerate, called Pulp Regeneration. Regeneration was first introduced in the dental field as a solution for immature apex treatment, due to difficulties encountered during its conventional root canal treatment. Here the Pulp regeneration shall be used on vital mature teeth to increase the survival rate of the affected teeth.
Interventions
PROCEDUREConventional
Conventional Blood Clot Technique
PROCEDUREPRF
Platelet Rich Fibrin Technique
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Masking description
Sealed Opaque Envelopes
Eligibility
Sex/Gender
ALL
Age
16 Years to 25 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients who are free from any physical or mental handicapping condition with no underlying systemic diseases. * Non-pregnant females * Single canalled teeth. * Patients having vital, mature, single rooted teeth, clinical evidence of pulpitis and apical periodontitis. * Positive patient/Guardian compliance for participation in the study.
Exclusion criteria
* Any known sensitivity or adverse reactions to medicaments or pharmaceuticals necessary to complete the trial. * Non-restorable coronal portion of teeth involved in the trial. * Non Vital teeth * Immature teeth * Traumatized teeth * Radiographic evidence of external or internal root resorption. * Single Rooted teeth with multiple canals.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of tooth Sensitivity | 1, 3, 6, 9, 12 Months | Electric Pulp Tester |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Survival | 1, 3, 6, 9, 12 Months | Clinical examination of tooth integrity |
| Clinical Success | 1, 3, 6, 9, 12 Months | Clinical examination the signs & symptoms is present or absent |
| Pericapical Status | 6, 9, 12 Months | CBCT assessment in Hounsfield unit |
| Periapical Status | 1, 3, 6, 9, 12 Months | Digital Periapical Radiograph in pixels |
Countries
Egypt
Contacts
Primary ContactMostafa O Fahim, MSc of Endodontics
Backup ContactAlaa Baz, Ass. Prof Endodontics
Outcome results
None listed