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Investigation of Psychophysiological Correlation of Aggression and Response to Aversive Stimuli

Investigation of Psychophysiological Correlation of Aggression and Response to Aversive Stimuli

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03725371
Enrollment
133
Registered
2018-10-31
Start date
2011-08-31
Completion date
2015-08-31
Last updated
2018-10-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ADHD, Conduct Disorder, Oppositional Defiant Disorder

Brief summary

This study investigates the psychophysiological correlations of aggression and response to aversive stimuli in a population of 133 children clinically diagnosed with conduct disorder (CD) and/or attention-deficit/hyperactivity disorder (ADHD). Data was gathered about participants' level of aggression through the Reactive-Proactive Aggression Questionnaire (RPQ). The stimuli that were presented to the participants included 1) a loud sound, 2) threatening photographs from the International Affective Picture System (IAPS), and 3) the Trier Social Stress Task (TSST). Participants' psychophysiological features of heart rate and galvanic skin conductance were measured and analyzed in relation to their RPQ scores and clinical diagnosis.

Interventions

OTHERNo intervention was administered for the purpose of this study.

No intervention was administered for the purpose of this study. Observations were carried out for all participants.

Sponsors

Yale-NUS College
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
7 Years to 16 Years
Healthy volunteers
No

Inclusion criteria

1. Subjects between ages 7 and 16 years 2. Subjects who fulfil all criteria for a DSM-IV diagnosis of ADHD, conduct disorder, or oppositional defiant disorder 3. Subjects with willingness to participate in a randomized, double-blind controlled trial 4. Subjects with complete written, informed parental consent and child assent 5. Subjects with IQ of 70 or more

Exclusion criteria

1. Subjects who have IQ in the below 70 2. Subjects who are younger than 7 years old or older than 16 years old 3. Those without written parental consent 4. Those with brain pathology such as serious head injury, epilepsy, etc.

Design outcomes

Primary

MeasureTime frameDescription
Heart Rate7 minutesFor Trier Social Stress Task
Skin Conductance Response4 minutesFor loud sound

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026