Healthy
Conditions
Keywords
Photophlethysmograph, device, pulse waveform
Brief summary
Aim 1. To explore a novel, non-invasive PPG technology for purposes of monitoring heart rate variability and pulse waveform by harmonic resonance analysis. Aim 2. To analyze collected data to determine whether it provides useful information about other measures of underlying health.
Detailed description
The proposed study will first investigate whether a novel PPG device will be able to measure the harmonic-analysis indexes of the blood pressure waveform (BPWs) to provide information about arterial pulse transmission (by monitoring arterial pulse waveform, Cn) and cardiovascular regulatory activities (by monitoring coefficients of variation, CVn). Secondarily, data on Cn and CVn could be useful for detecting the arterial elastic properties induced by external stimulation such as exercise, cold stimulation, mental stress, acupuncture, medications such as antihypertensive drugs, or pathological factors such as metabolic syndrome, and breast cancer. The collected data may thus provide information about underlying health. Photoplethysmography (PPG) is a non-invasive optical technique for evaluating the pulse and hemodynamic changes in frequency. The device obtains a volumetric measurement of an organ via optical illumination (e.g LED). PPG has been used to determine the PaO2, heart rate, and blood pressure (systolic blood pressure, SBP and diastolic blood pressure, DBP) at fingertip and harmonic proportion at fingertip or from the radial artery waveform at the wrist. However, to the investigator's knowledge, this is the first preliminary study to determine the effects of physical activity on harmonic proportion evaluating by PPG at fingertip. Ultimately, this data may help to develop a non-invasive, external device that could rapidly detect information about cardiovascular and underlying health.
Interventions
DEVICEPPG during exercise
PPG use for pulse waveform evaluation of healthy exercise group
Sponsors
National Taiwan Normal University
University of California, Los Angeles
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DEVICE_FEASIBILITY
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
4\) Inclusion criteria: 1. Ability to understand consent (no proxy consent) in English or Chinese. 2. Self-Reported ability to undertake a 20 minute cycling activity at 60-70% exercise intensity. 3. Ability and willingness to abstain from use of medications for three days preceding cycling activity, smoking/intense exercise/alcohol for 12 hours preceding cycling activity, and caffeine intake for 4 hours preceding cycling. 5\)
Exclusion criteria
1. Inability to finish a 20 min cycling activity in 60-70% exercise intensity. 2. Adverse reaction to adhesive tape. 3. Raynaud's phenomenon 4. Angina or recent myocardial infarction (previous 6 months)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Harmonic measures (C1-C10) by PPG device | 70 minutes on Day 1 for resting, exercise, and cool down measurements | C1-C10 by PPG device |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| General health | Day 1 | General health questionnaire |
| Weight | Day 1 | Weight |
| Height | Day 1 | Height |
| Body mass index (BMI) | Day 1 | Body mass index (BMI) |
| Demographic Information | Day 1 | Collected from patients by questionnaire |
| Systolic blood pressure (SBP) | 70 minutes on Day 1 for resting, exercise, and cool down measurements | iHealth Feel Wireless blood pressure monitor |
| HRV measures (SDNN, HF, LF and HF/LF parameters) | 70 minutes on Day 1 for resting, exercise, and cool down measurements | emWave Pro plus, SDNN indicates standard deviation of normal to normal R-R intervals, where R is the peak of a QRS complex (heartbeat). LF and HF represent power in low- and high-frequency ranges |
| Heart rate and Heart Rate Variation | 70 minutes on Day 1 for resting, exercise, and cool down measurements | emWave Pro Plus |
| Diastolic blood pressure (DBP) | 70 minutes on Day 1 for resting, exercise, and cool down measurements | iHealth Feel Wireless blood pressure monitor |
Countries
Taiwan
Outcome results
None listed