Dyslipidemias, Obesity
Conditions
Keywords
Adropin, adiponectin, testosterone, obese men
Brief summary
Obesity is associated with low testosterone in men and with dyslipidemia. Adropin hormone is negatively correlated with body mass index and is associated with dyslipidemia. correlation between adropin and testosterone will be evaluated.
Detailed description
Obesity, a worldwide epidemic is associated with multiple adverse health outcome as diabetes mellitus, hypertension and cardiovascular diseases caused mainly by dyslipidemia linked to obesity. Low testosterone levels in obese men were found associated with dyslipidemia. Adropin is a new metabolic hormone that was first isolated in liver and brain tissues, It was observed that mice fed on a high-fat diet (HFD) had a rapid increase in adropin expression compared to control values. In human also, adropin levels were negatively correlated with body mass index (BMI) and were associated with dyslipidemia. Adiponectin is a protein that is mainly produced by white adipose tissue and has an important role in lipid metabolism. Serum adiponectin concentrations were decreased in obese compared to normal weight men and significantly correlated with testosterone level.
Interventions
DIAGNOSTIC_TESTlipid profile: Total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL))
blood samples will be collected after 10 hours fasting
DIAGNOSTIC_TESTTotal testosterone
blood samples will be collected after 10 hours fasting
DIAGNOSTIC_TESTAdropin
blood samples will be collected after 10 hours fasting
DIAGNOSTIC_TESTAdiponectin
blood samples will be collected after 10 hours fasting
Sponsors
Aswan University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
MALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Age from 18 years to 50 years. Clinically free except from obesity
Exclusion criteria
* Diabetes mellitus Hypertension Heart failure Kidney disease Smoking
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes in lipid profile (TC, TG, LDL, HDL) levels | 6 months | expected higher TC, TG, LDl levels and lower HDL levels in obese men compared to normal |
| changes in total testosterone levels | 6 months | expected lower testosterone levels in obese men compared to normal men |
| changes in adropin level | 6 months | expected lower adropin levels in obese men compared to normal men |
| changed in adiponectin levels | 6 months | expected lower adiponectin level in obese men compared to normal men |
| correlation between adropin and testosterone | 6 months | — |
| correlation between adropin and adiponectin | 6 months | — |
Countries
Egypt
Outcome results
None listed