High Altitude Area- A Risk Factor For Gastric Perforation?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03724513

Enrollment

Registered

2018-10-30

Start date

2018-09-15

Completion date

2018-10-10

Last updated

2018-10-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastric Perforation

Keywords

High Altitude, Gastric Antrum Perforation, Mucosal Atrophy, Intra Luminal Pressure

Brief summary

This is an original case series on soldiers evacuated from HAA(High Altitude Area) over last one year(Sept 2017- Aug 2018) , of which 100% cases were found to have gastric antrum perforation. This is a deviation from the usual trend that is being noted in Indian subcontinent where duodenal perforations are commonest.

Detailed description

INTRODUCTION : This is an original case series on soldiers evacuated from HAA(High Altitude Area) over last one year(Sept 2017- Aug 2018) , of which 100% cases were found to have gastric antrum perforation. This is a deviation from the usual trend that is being noted in Indian subcontinent where duodenal perforations are commonest. DISCUSSION : High altitude associated dyspepsia is a common phenomenon and some studies done in high altitude population have recorded high incidence of antral gastritis and mucosal atrophy on histo-pathological evaluation. This is also supported by high incidence of H.pylori infection. The presence of atrophic gastric mucosa associated with antral gastritis, when exposed to hypobaric hypoxemic conditions faced by soldiers posted to heights above 15000ft , may leads to increased intra-luminal pressure and ischemia which probably predisposes individuals for gastric antrum perforations. CONCLUSION : This is a relatively untouched topic as we have not found studies on high altitude related gastric perforations and probably this is the first case series of its kind. The acknowledgement of this phenomenon may pave way for further studies for defining the role of high altitude in gastric perforations.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

MALE

Healthy volunteers

Inclusion criteria

* Individuals located in High Altitude Area (\>10,000ft). * presented as perforation peritonitis. * intra-operatively found to be perforated peptic ulcers.

Exclusion criteria

* Not located in High Altitude Area. * intra-operatively perfoarations sites other then stomach and duodenum.

Design outcomes

Primary

Measure	Time frame	Description
Assessment of site of perforated peptic ulcers by intra-operative observation in cases evacuated from High Altitude Area.	1 year	Study aims at recording the site of perforated peptic ulcers in cases being evacuated in individuals posted at High Altitude Area.

Countries

India

Outcome results