Airway Management During TCI vs RSI Anesthesia Induction

Airway Management and Safety Aspects During Target Controlled Infusion (TCI) Compared to Rapid Sequence Induction (RSI) of Anesthesia in Non-cardiac Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03723109

Enrollment

Registered

2018-10-29

Start date

2018-10-29

Completion date

2019-05-31

Last updated

2019-09-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adverse Effect, Airway Complication of Anesthesia, Anesthesia

Brief summary

The aims of this observational study is to evaluate and compare feasibility of airway management during standardized TCI and RSI anesthesia induction.

Detailed description

The aims of this study are to evaluate and compare feasibility of airway management and risk for desaturation during standardized target controlled infusion (TCI) and rapid sequence induction (RSI) of anesthesia. A conventional way to induce anesthesia, i.e. manual injection of anesthetics, may be more accurate and predictable compared to dosing regimes based on complex mathematical algorithms used in TCI-systems. In addition, today many different models are presented and there is no consensus which kind of TCI-algorithm should be used universally. Moreover, dosing algorithms are most complex and challenging in underweight and morbid obesity. There are many publications on this field, but no data of feasibility of airway management can be found. Indeed, RSI induction is traditionally blamed to be risky and not recommended as a first choice.

Interventions

PROCEDUREInduction of anesthesia

Standardized TCI and RSI anesthesia induction

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* signed informed consent * BMI \< 35 kg/m2 * preoperative assessment accepted by consultant anesthesiologist * scheduled for breast cancer surgery, endocrinological surgery (thyroid, parathyroid) or minor general abdominal surgery.

Exclusion criteria

* not signed consent * instable angina pectoris * severe bronchial asthma * severe chronic obstructive pulmonary disease * dementia * severe heart valve disease * severe renal failure * body mass index \> 35 kg/m2

Design outcomes

Primary

Measure	Time frame	Description
Safety time for apnea	10min	measurement of length of period for apnea during TCI and RSI induction by a timer

Secondary

Measure	Time frame	Description
Duration of spontaneous breathing	10min	measurement of duration of spontaneous breathing during TCI and RSI induction by a timer

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026