Healthy, Physical Activity
Conditions
Keywords
Exercise, Treadmill, Vascular Function, Intensity
Brief summary
Cerebrovascular function and peripheral vascular function will be measured in healthy young adults, before and after acute bouts of aerobic exercise at various intensities.
Detailed description
Acute bouts of aerobic exercise have been shown to enhance vascular reactivity of the peripheral circulation; however, the effects of a single exercise session on the cerebral circulation are unknown. This study will measure cerebrovascular function and peripheral vascular function before and after aerobic exercise at high and low intensities. The research aims are: 1. To determine if a single bout of aerobic exercise acutely enhances cerebrovascular function 2. To determine the effect of aerobic exercise intensity and dose on cerebrovascular function in healthy adults. 3. To determine if the acute exercise-induced changes in cerebrovascular function are associated with acute exercise-induced changes in peripheral vascular function in healthy adults.
Interventions
OTHERControl
1. Ultrasound 2. Blood Pressure 3. Heart Rate 4. Oxygen Saturation
OTHERAerobic Exercise
1. Ultrasound 2. Blood Pressure 3. Heart Rate 4. Oxygen Saturation
Sponsors
University of Wisconsin, Madison
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Between 20-40 years old * BMI \< 30 kg/m2 * Recreationally active * Experience running on a treadmill
Exclusion criteria
* Current smoker * History or evidence of: hepatic disease, renal disease, hematological disease, cardiovascular disease, stroke/neurovascular disease, diabetes * Taking blood pressure medication * History of depression or other mood related disorders * Part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking capacity to consent, etc.)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cerebrovascular function | Change in cerebrovascular function: measurements occur at baseline and 90 minutes post aerobic exercise to quantify magnitude of change. | Utilize ultrasound to measure a change in blood flow velocity in response to a breathing test |
| Peripheral vascular function | Change in peripheral vascular function: measurements occur at baseline and 60 minutes post aerobic exercise to quantify magnitude of change. | Utilize ultrasound to measure a change in brachial artery diameter in response to reactive hyperemia |
Countries
United States
Outcome results
None listed