Diagnostic Value and Biological Significant of cd71 in Lymphoid Disorders

Diagnostic Value and Biological Significant of cd71 in Lymphoid Dis Order

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03720977

Enrollment

139

Registered

2018-10-26

Start date

2019-12-01

Completion date

2020-12-01

Last updated

2018-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cd71, Lyphoid Disorders

Brief summary

CD71 is expressed on activated B and T cells, macrophages, reticulocytes, erythroid precursors, and malignant tissues. , reflecting the requirement for iron in hemoglobin. , CD71 expression is upregulated on immature proliferating cells and low levels on resting mature lymphocytes. In addition to this general function, CD71 appears to play a costimulatory role in T cell activation and receptor for IgA1 antibodies So it is growth receptor that may help in diagnosis of lymphoid disorder and in differentiation of malignant and benign that will be studied investigate CD71 expression in lymphoid disorders and its diagnostic value ,we from collect data patient and do rotune examination

Detailed description

1. Routine investigations for diagnosis: * CBC. * Bone marrow aspiration morphology. * Cytochemistry. * Flow cytometry immunophenotyping. * Bone marrow biopsy when indicated. 2. Special investigation is flow cytometry examination of CD71 expression. sample size calculation ; sample size cases 39 sample size controls 39 total sample size 79 sample will be collected from patient in hospital university ,Data will be analysed by SPSS program

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* all patients wiil be diagnosed lymphoid disorders

Exclusion criteria

* not present

Design outcomes

Primary

Measure	Time frame	Description
determin diagnostic value of cd71 in lymphoid disorder	baseline	Routine investigations for diagnosis: CBC. Bone marrow aspiration morphology. Cytochemistry. Flow cytometry immunophenotyping. Bone marrow biopsy when indicated. Special investigation is flow cytometry examination of CD71 expression. total sample size 79 person .sample will be collected from patient in hospital university ,Data will be analysed by SPSS program it is growth receptor is expressed on activated B and T cells, macrophages, reticulocytes, erythroid precursors, and malignant tissues

Contacts

Primary ContactMarwa Aboelim

marwaaboelim@gmail.com01012636292

Backup ContactTagreed kamal, dr

01002286687

Outcome results