Vascular Parkinsonism
Conditions
Keywords
parkinsonism, vascular parkinsonism, repetitive transcranial magnetic stimulation, brain stimulation
Brief summary
Vascular parkinsonism (VP), parkinsonism resulting from ischemic cerebrovascular disease, was suggested in 1929. The main features are wide-based gait, postural instability, and falls, which make patients with VP frustrated. Currently, the treatment is challenging. Transcranial magnetic stiumation is a noninvasive procedure using electromagnetic induction to stimulate brain, and repetitive transcranial magnetic stiumation (rTMS) can selectively change brain activity to enhance desired effects. The aim of this study is to explore the therapeutic effect of rTMS for the VP.
Interventions
DEVICEReal rTMS Supplementary motor area
There will be a series of four rTMS blocks separated by 10 minutes. Each block will consist of 15 to 25 pulse trains of 1-second duration at 25 Hz, with an intertrain interval of 10 seconds.
DEVICESham rTMS Supplementary motor area
There will be no real brain stimulation in Sham rTMS, and participant will be blinded.
Sponsors
Dongtan Sacred Heart Hospital
Inje University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Vascular parkinsonism * age 18 and older
Exclusion criteria
* pregnant or any, other medical, surgical, neurological or psychiatric conditions * other restrictions which prevent you from undergoing TMS recording, such as; surgically or traumatically implanted foreign bodies such as a pacemaker, an implanted medication pump, a metal plate in the skull, or metal inside the skull or eyes (other than dental appliances or fillings), and/ or heart/cardiac lines * any past or current history of seizure disorder or epilepsy * unable to give informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Unified Parkinson's Disease Rating Scale (UPDRS) part III-motor part (Number 18 ~31 of UPDRS) | 2 days | Motor functions will be checked using UPDRS. Each item of the motor part ranges from 0 to 4 (0 means normal, 4 means worst condition). Total sum will be calculated. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Finger tapping test with right hand | 2 days | Finger tapping test with right hand, as quickly as possible for 15 second. The total number of taps will be calculated. The test will be twice with one minute interval. After the test performed twice, the average of the tests will be used. |
| The total number of steps during the stand-walk-sit (SWS) test | 2 days | SWS test is Standing up, making a 9 m round trip, and sitting down as quickly as possible. The number of steps will be recorded. |
| The completion time during the SWS test | 2 days | The completion time will be recorded. |
| Freezing episodes of gait trajectory | 2 days | The number of freezing episodes during rapid full turns and dual task |
| Patient and Clinical Global Impression Scale | 2 days | 7-point scale that requires the patient (or clinician) to rate the response of the interventions. The rating will be numbered (1: very much improved; 2: much improved; 3: minimally improved; 4: no changes; 5: minimally worse; 6: much worse; 7: very much worse). |
Countries
South Korea
Contacts
Primary ContactSang Jin Kim, MD, PhD
Outcome results
None listed